Detection limit improvement of surface plasmon resonance based biosensors using statistical hypothesis testing

Anne Barnett; Ewa M. Goldys; Konrad Dybek

doi:10.1117/12.590218

Detection limit improvement of surface plasmon resonance based biosensors using statistical hypothesis testing

Anne Barnett^*, Ewa M. Goldys, Konrad Dybek

^*Corresponding author for this work

Faculty of Science and Engineering

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

We propose a new approach to improving the resolution of a Surface Plasmon Resonance (SPR) based biosensing system through the use of the statistical technique of hypothesis testing. Simulated SPR reflectance curves at the wavelength of 632.8 nm in the Kretschmann configuration were generated. Detector specifications were taken from Ames Photonics CMOS Larry-CCD 1024 array detector with a total integration time of 100s and a noise amplitude relative to signal σ = 3 × 10^-6. We were able to achieve the detection limit of the refractive index difference with respect to water of Δn = 4 × 10^-8 with 95% significance level.

Original language	English
Article number	10
Pages (from-to)	71-78
Number of pages	8
Journal	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	5703
DOIs	https://doi.org/10.1117/12.590218
Publication status	Published - 2005

Keywords

Detection Limit
Hypothesis Testing
Surface Plasmon Resonance

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10.1117/12.590218

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abstract = "We propose a new approach to improving the resolution of a Surface Plasmon Resonance (SPR) based biosensing system through the use of the statistical technique of hypothesis testing. Simulated SPR reflectance curves at the wavelength of 632.8 nm in the Kretschmann configuration were generated. Detector specifications were taken from Ames Photonics CMOS Larry-CCD 1024 array detector with a total integration time of 100s and a noise amplitude relative to signal σ = 3 × 10-6. We were able to achieve the detection limit of the refractive index difference with respect to water of Δn = 4 × 10-8 with 95% significance level.",

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AU - Barnett, Anne

AU - Goldys, Ewa M.

AU - Dybek, Konrad

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AB - We propose a new approach to improving the resolution of a Surface Plasmon Resonance (SPR) based biosensing system through the use of the statistical technique of hypothesis testing. Simulated SPR reflectance curves at the wavelength of 632.8 nm in the Kretschmann configuration were generated. Detector specifications were taken from Ames Photonics CMOS Larry-CCD 1024 array detector with a total integration time of 100s and a noise amplitude relative to signal σ = 3 × 10-6. We were able to achieve the detection limit of the refractive index difference with respect to water of Δn = 4 × 10-8 with 95% significance level.

KW - Detection Limit

KW - Hypothesis Testing

KW - Surface Plasmon Resonance

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JF - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

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ER -

Detection limit improvement of surface plasmon resonance based biosensors using statistical hypothesis testing

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Keywords

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