Detection of Chlamydophila pneumoniae DNA in peripheral blood mononuclear cells of blood donors in the north-east of Italy

Mario Rassu*, Federico M. Lauro, Stefania Cazzavillan, Emanuela Bonoldi, Maurizio Belloni, Maria C. Bettini, Alberto Pilotto, Carlo Mengoli, Antonella Peron, Renato Zambello, Mariuccia Scagnelli, Giulio Bertoloni

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Recent studies have implicated Chlamydia pneumoniae (now Chlamydophila pneumoniae) in the pathogenesis of atherosclerosis and demonstrated its presence within human peripheral blood mononuclear cells (PBMCs). In this study the presence of C. pneumoniae DNA was assessed, using nested PCR, in PBMCs from 169 active blood donors as a function of age, of specific antibodies and C-reactive protein. The results obtained demonstrated a high degree of global positivity (46.15%), which was higher in females (52%) than in males (43.7%). Seroepidemiological studies showed a high percentage of positivity both in subjects positive by PCR (65.91%) and negative by PCR (71.74%). The clinical implication of such finding are under study.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalMedical Microbiology and Immunology
Volume190
Issue number3
Publication statusPublished - 2001
Externally publishedYes

Keywords

  • Antibodies
  • Blood donors
  • Chlamydophila pneumoniae
  • Peripheral blood mononuclear cells
  • Polymerase chain reaction

Fingerprint Dive into the research topics of 'Detection of Chlamydophila pneumoniae DNA in peripheral blood mononuclear cells of blood donors in the north-east of Italy'. Together they form a unique fingerprint.

Cite this