Determinants of arterial stiffness in children using population-indexed anthropometric and hemodynamic parameters

Tommy Cai, Alice Meroni, Ahmad Qasem, Mark Butlin, Julian Ayer, David Celermajer, Alberto Avolio, Michael Skilton

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    Background: Arterial stiffness is a significant cardiovascular risk factor. Carotid-femoral pulse wave velocity (cfPWV) is the standard for measuring arterial stiffness, but indices such as central augmentation index (cAIx) and carotid artery elasticity (cE[p]) also correlate to arterial stiffness. Early-life determinants of arterial stiffening are not well understood. We assessed the relationship between population-indexed anthropometric and hemodynamic parameters, and arterial stiffness in healthy children.Methods: 97 healthy children between 2 to 20 years old were recruited. Z-scores for height, BMI, and brachial systolic (bSBP) and diastolic (bDBP) blood pressure were calculated [1,2]. cfPWV and central arterial waveforms were measured using the Sphygmocor XCEL and CvMS devices (AtCor, Sydney) respectively. Carotid artery maximum and minimum diameters were measured by high-resolution ultrasonography. cfPWV, cE[p], and cAIx were calculated.Results: In bivariate analysis, cfPWV was associated with age (b = 0.52, p < 0.01) and bSBP z-score (b = 0.24, p = 0.03). These associations were independent of sex, height z-score, BMI z-score, and bDBP z-score in a multivariable model (R2 = 0.23). cE[p] was significantly associated with age (b = 0.42, p < 0.01), bSBP z-score (b = 0.45, p < 0.01), and height z-score (b = −0.33, p = 0.01), but only bSBP z-score remained statistically significant in the multivariable model (b = 0.45, p < 0.01; R2 = 0.20). cAIx was not associated with anthropometric or hemodynamic z-scores.Conclusion: cfPWV is associated with age and bSBP z-score, while cE[p] is associated with bSBP z-score only, suggesting a potentially key association between systolic blood pressure and indices of arterial stiffness independent of age and other parameters of growth during healthy early life.
    Original languageEnglish
    Article numberP136
    Pages (from-to)S174
    Number of pages1
    JournalArtery Research
    Issue numberSupplement 1
    Publication statusPublished - 2019
    EventAssociation for Research into Arterial Structure and Physiology Conference 2019: ARTERY 2019 - Budapest, Hungary
    Duration: 10 Oct 201912 Oct 2019

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    Copyright the Association for Research into Arterial Structure and Physiology 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


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