Determinants of arterial stiffness in COPD

Surya P. Bhatt*, Adam G. Cole, James M. Wells, Hrudaya Nath, Jubal R. Watts, John R. Cockcroft, Mark T. Dransfield

*Corresponding author for this work

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Abstract

Background: Cardiovascular morbidity and mortality is high in patients with chronic obstructive pulmonary disease (COPD) and arterial stiffness is a potentially modifiable risk factor with added predictive value beyond that obtained from traditional risk factors. Arterial stiffness has been the target of pharmacologic and exercise interventions in patients with COPD, but the effects appear limited to those patients with more significant elevations in arterial stiffness. We aimed to identify predictors of increased arterial stiffness in a cohort with moderate to severe COPD.Methods: Aortic pulse wave velocity (aPWV) was measured in subjects with moderate to severe COPD enrolled in a multicenter randomized controlled trial. Subjects were categorized into quartiles based on aPWV values and factors affecting high arterial stiffness were assessed. Multivariate models were created to identify independent predictors of high aPWV, and cardiovascular disease (CVD).Results: 153 patients were included. Mean age was 63.2 (SD 8.2) years and mean FEV1 was 55.4 (SD 15.2) % predicted. Compared to the quartile with the lowest aPWV, subjects in the highest quartile were older, had higher systolic blood pressure (SBP), were more likely to be current smokers, and had greater burden of thoracic aortic calcification. On multivariate analyses, age (adjusted OR 1.14, 95%CI 1.05 to 1.25, p = 0.003) and SBP (adjusted OR 1.06, 95% CI 1.02 to 1.09, p = 0.001) were independent predictors of elevated aPWV. Body mass index, therapy with cholesterol lowering medications and coronary calcification were independent predictors of CVD.Conclusions: Elevated arterial stiffness in patients with COPD can be predicted using age, blood pressure and thoracic aortic calcification. This will help identify subjects for enrollment in clinical trials using aPWV for assessing the impact of COPD therapies on CV outcomes.Trial registration: Clinicaltrials.gov NCT00857766.

Original languageEnglish
Article number1
Pages (from-to)1-7
Number of pages7
JournalBMC Pulmonary Medicine
Volume14
Issue number1
DOIs
Publication statusPublished - 4 Jan 2014
Externally publishedYes

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Bibliographical note

Copyright the Author(s) 2014. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Arterial calcification
  • Arterial stiffness
  • Cardiovascular
  • COPD

Cite this

Bhatt, S. P., Cole, A. G., Wells, J. M., Nath, H., Watts, J. R., Cockcroft, J. R., & Dransfield, M. T. (2014). Determinants of arterial stiffness in COPD. BMC Pulmonary Medicine, 14(1), 1-7. [1]. https://doi.org/10.1186/1471-2466-14-1