Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors

‘Establishing normal and reference values’

Francesco U S Mattace-Raso, Albert Hofman, Germaine C. Verwoert, Jacqueline C M Wittemana, Ian Wilkinson, John Cockcroft, Carmel McEniery, Yasmina, Stéphane Laurent, Pierre Boutouyrie*, Erwan Bozec, Tine Willum Hansen, Christian Torp-Pedersen, Hans Ibsen, Jørgen Jeppesen, Sebastian J. Vermeersch, Ernst Rietzschel, Marc de Buyzere, Thierry C. Gillebert, Luc van Bortel & 28 others Patrick Segers, Charalambos Vlachopoulos, Constantinos Aznaouridis, Christodoulos Stefanadis, Athanase Benetos, Carlos Labat, Patrick Lacolley, Coen D A Stehouwer, Giel Nijpels, Jacqueline M. Dekker, Isabel Ferreira, Jos W R Twisk, Sebastien Czernichow, Pilar Galan, Serge Hercberg, Bruno Pannier, Alain Guérin, Gérard London, J. Kennedy Cruickshank, Simon G. Anderson, Anna Paini, Enrico Agabiti Rosei, Maria Lorenza Muiesan, Massimo Salvetti, Jan Filipovsky, Jitka Seidlerova, Milena Dolejsova, The Reference Values For Arterial Stiffness’ Collaboration

*Corresponding author for this work

    Research output: Contribution to journalArticle

    999 Citations (Scopus)

    Abstract

    Aims Carotid–femoral pulse wave velocity (PWV), a direct measure of aortic stiffness, has become increasingly important for total cardiovascular (CV) risk estimation. Its application as a routine tool for clinical patient evaluation has been hampered by the absence of reference values. The aim of the present study is to establish reference and normal values for PWV based on a large European population. Methods and results We gathered data from 16 867 subjects and patients from 13 different centres across eight European countries, in which PWV and basic clinical parameters were measured. Of these, 11 092 individuals were free from overt CV disease, non-diabetic and untreated by either anti-hypertensive or lipid-lowering drugs and constituted the reference value population, of which the subset with optimal/normal blood pressures (BPs) (n = 1455) is the normal value population. Prior to data pooling, PWV values were converted to a common standard using established conversion formulae. Subjects were categorized by age decade and further subdivided according to BP categories. Pulse wave velocity increased with age and BP category; the increase with age being more pronounced for higher BP categories and the increase with BP being more important for older subjects. The distribution of PWV with age and BP category is described and reference values for PWV are established. Normal values are proposed based on the PWV values observed in the non-hypertensive subpopulation who had no additional CV risk factors. Conclusion The present study is the first to establish reference and normal values for PWV, combining a sizeable European population after standardizing results for different methods of PWV measurement.

    Original languageEnglish
    Pages (from-to)2338-2350
    Number of pages13
    JournalEuropean Heart Journal
    Volume31
    Issue number19
    DOIs
    Publication statusPublished - 2010

    Keywords

    • Aged
    • Arteries
    • Arteriosclerosis
    • Blood pressure
    • Dult
    • Humans
    • Pulse
    • Pulse wave velocity
    • Stiffness

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