Determination of wall tension in cerebral artery aneurysms by numerical simulation

Jørgen Gjernes Isaksen, Yuri Bazilevs, Trond Kvamsdal, Yongjie Zhang, Jon H. Kaspersen, Knut Waterloo, Bertil Romner, Tor Ingebrigtsen*

*Corresponding author for this work

Research output: Contribution to journalArticle

119 Citations (Scopus)


Background and Purpose: Cerebral artery aneurysms rupture when wall tension exceeds the strength of the wall tissue. At present, risk-assessment of unruptured aneurysms does not include evaluation of the lesions shape, yet clinical experience suggests that this is of importance. We aimed to develop a computational model for simulation of fluid-structure interaction in cerebral aneurysms based on patient specific lesion geometry, with special emphasis on wall tension. Methods: An advanced isogeometric fluid-structure analysis model incorporating flexible aneurysm wall based on patient specific computed tomography angiogram images was developed. Variables used in the simulation model were retrieved from a literature review. Results: The simulation results exposed areas of high wall tension and wall displacement located where aneurysms usually rupture. Conclusion: We suggest that analyzing wall tension and wall displacement in cerebral aneurysms by numeric simulation could be developed into a novel method for individualized prediction of rupture risk.

Original languageEnglish
Pages (from-to)3172-3178
Number of pages7
Issue number12
Publication statusPublished - 1 Dec 2008
Externally publishedYes


  • Computer assisted numerical analysis
  • Intracranial aneurysm
  • Risk
  • Rupture
  • Tension

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    Isaksen, J. G., Bazilevs, Y., Kvamsdal, T., Zhang, Y., Kaspersen, J. H., Waterloo, K., ... Ingebrigtsen, T. (2008). Determination of wall tension in cerebral artery aneurysms by numerical simulation. Stroke, 39(12), 3172-3178.