TY - JOUR
T1 - Deterministic lateral displacement
T2 - challenges and perspectives
AU - Hochstetter, Axel
AU - Vernekar, Rohan
AU - Austin, Robert H.
AU - Becker, Holger
AU - Beech, Jason P.
AU - Fedosov, Dmitry A.
AU - Gompper, Gerhard
AU - Kim, Sung-Cheol
AU - Smith, Joshua T.
AU - Stolovitzky, Gustavo
AU - Tegenfeldt, Jonas O.
AU - Wunsch, Benjamin H.
AU - Zeming, Kerwin K.
AU - Krüger, Timm
AU - Inglis, David W.
PY - 2020/9/22
Y1 - 2020/9/22
N2 - The advent of microfluidics in the 1990s promised a revolution in multiple industries from healthcare to chemical processing. Deterministic lateral displacement (DLD) is a continuous-flow microfluidic particle separation method discovered in 2004 that has been applied successfully and widely to the separation of blood cells, yeast, spores, bacteria, viruses, DNA, droplets, and more. Deterministic lateral displacement is conceptually simple and can deliver consistent performance over a wide range of flow rates and particle concentrations. Despite wide use and in-depth study, DLD has not yet been fully elucidated or optimized, with different approaches to the same problem yielding varying results. We endeavor here to provide up-to-date expert opinion on the state-of-art and current fundamental, practical, and commercial challenges with DLD as well as describe experimental and modeling opportunities. Because these challenges and opportunities arise from constraints on hydrodynamics, fabrication, and operation at the micro- and nanoscale, we expect this Perspective to serve as a guide for the broader micro- and nanofluidic community to identify and to address open questions in the field.[Graphic presents]
AB - The advent of microfluidics in the 1990s promised a revolution in multiple industries from healthcare to chemical processing. Deterministic lateral displacement (DLD) is a continuous-flow microfluidic particle separation method discovered in 2004 that has been applied successfully and widely to the separation of blood cells, yeast, spores, bacteria, viruses, DNA, droplets, and more. Deterministic lateral displacement is conceptually simple and can deliver consistent performance over a wide range of flow rates and particle concentrations. Despite wide use and in-depth study, DLD has not yet been fully elucidated or optimized, with different approaches to the same problem yielding varying results. We endeavor here to provide up-to-date expert opinion on the state-of-art and current fundamental, practical, and commercial challenges with DLD as well as describe experimental and modeling opportunities. Because these challenges and opportunities arise from constraints on hydrodynamics, fabrication, and operation at the micro- and nanoscale, we expect this Perspective to serve as a guide for the broader micro- and nanofluidic community to identify and to address open questions in the field.[Graphic presents]
UR - http://www.scopus.com/inward/record.url?scp=85091043486&partnerID=8YFLogxK
U2 - 10.1021/acsnano.0c05186
DO - 10.1021/acsnano.0c05186
M3 - Review article
C2 - 32844655
AN - SCOPUS:85091043486
SN - 1936-0851
VL - 14
SP - 10784
EP - 10795
JO - ACS Nano
JF - ACS Nano
IS - 9
ER -