Deterministic lateral displacement occurs without contact at inertial flow rates

William J. Monck; Calum P. Mallorie; Rohan R. Vernekar; Timm Krüger; David W. Inglis

Deterministic lateral displacement occurs without contact at inertial flow rates

William J. Monck, Calum P. Mallorie, Rohan R. Vernekar, Timm Krüger, David W. Inglis^*

^*Corresponding author for this work

School of Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution

Abstract

The movement of microparticles through microfluidic systems is relevant to a wide range of technologies. Modelling the flow field in the absence of particles is routine. However, predicting the path of particles is challenging as it results from non-steady-state interactions between the fluid boundaries, the pressure gradient and the particle. Lattice Boltzman method (LBM) is able to accurately solve this dynamic problem, and is here applied to Deterministic Lateral Displacement (DLD) microfluidics. We show that inertia causes i) separation without post-pillar contact and ii) reduced critical particle size. We also show that simulations in 2D exaggerate the magnitude of this reduction.

Original language	English
Title of host publication	24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Place of Publication	San Diego, California
Publisher	Chemical and Biological Microsystems Society
Pages	649-650
Number of pages	2
ISBN (Electronic)	9781733419017
Publication status	Published - 2020
Event	24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online Duration: 4 Oct 2020 → 9 Oct 2020

Conference

Conference	24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
City	Virtual, Online
Period	4/10/20 → 9/10/20

Keywords

High throughput
deterministic lateral displacement
inertial microfluidics
modelling
simulation

Cite this

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title = "Deterministic lateral displacement occurs without contact at inertial flow rates",

abstract = "The movement of microparticles through microfluidic systems is relevant to a wide range of technologies. Modelling the flow field in the absence of particles is routine. However, predicting the path of particles is challenging as it results from non-steady-state interactions between the fluid boundaries, the pressure gradient and the particle. Lattice Boltzman method (LBM) is able to accurately solve this dynamic problem, and is here applied to Deterministic Lateral Displacement (DLD) microfluidics. We show that inertia causes i) separation without post-pillar contact and ii) reduced critical particle size. We also show that simulations in 2D exaggerate the magnitude of this reduction.",

keywords = "High throughput, deterministic lateral displacement, inertial microfluidics, modelling, simulation",

author = "Monck, {William J.} and Mallorie, {Calum P.} and Vernekar, {Rohan R.} and Timm Kr{\"u}ger and Inglis, {David W.}",

year = "2020",

language = "English",

pages = "649--650",

booktitle = "24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

publisher = "Chemical and Biological Microsystems Society",

note = "24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 ; Conference date: 04-10-2020 Through 09-10-2020",

}

Monck, WJ, Mallorie, CP, Vernekar, RR, Krüger, T & Inglis, DW 2020, Deterministic lateral displacement occurs without contact at inertial flow rates. in 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, San Diego, California, pp. 649-650, 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020, Virtual, Online, 4/10/20.

Deterministic lateral displacement occurs without contact at inertial flow rates. / Monck, William J.; Mallorie, Calum P.; Vernekar, Rohan R. et al.
24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. San Diego, California: Chemical and Biological Microsystems Society, 2020. p. 649-650.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution

TY - GEN

T1 - Deterministic lateral displacement occurs without contact at inertial flow rates

AU - Monck, William J.

AU - Mallorie, Calum P.

AU - Vernekar, Rohan R.

AU - Krüger, Timm

AU - Inglis, David W.

PY - 2020

Y1 - 2020

N2 - The movement of microparticles through microfluidic systems is relevant to a wide range of technologies. Modelling the flow field in the absence of particles is routine. However, predicting the path of particles is challenging as it results from non-steady-state interactions between the fluid boundaries, the pressure gradient and the particle. Lattice Boltzman method (LBM) is able to accurately solve this dynamic problem, and is here applied to Deterministic Lateral Displacement (DLD) microfluidics. We show that inertia causes i) separation without post-pillar contact and ii) reduced critical particle size. We also show that simulations in 2D exaggerate the magnitude of this reduction.

AB - The movement of microparticles through microfluidic systems is relevant to a wide range of technologies. Modelling the flow field in the absence of particles is routine. However, predicting the path of particles is challenging as it results from non-steady-state interactions between the fluid boundaries, the pressure gradient and the particle. Lattice Boltzman method (LBM) is able to accurately solve this dynamic problem, and is here applied to Deterministic Lateral Displacement (DLD) microfluidics. We show that inertia causes i) separation without post-pillar contact and ii) reduced critical particle size. We also show that simulations in 2D exaggerate the magnitude of this reduction.

KW - High throughput

KW - deterministic lateral displacement

KW - inertial microfluidics

KW - modelling

KW - simulation

UR - http://www.scopus.com/inward/record.url?scp=85098260239&partnerID=8YFLogxK

UR - https://cbmsociety.org/conference/proceedings_archive.html

M3 - Conference proceeding contribution

AN - SCOPUS:85098260239

SP - 649

EP - 650

BT - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - Chemical and Biological Microsystems Society

CY - San Diego, California

T2 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020

Y2 - 4 October 2020 through 9 October 2020

ER -

Deterministic lateral displacement occurs without contact at inertial flow rates

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