Developing an international network for Alzheimer research

The Dominantly Inherited Alzheimer Network

John C. Morris, Paul S. Aisen, Randall J. Bateman, Tammie L S Benzinger, Nigel J. Cairns, Anne M. Fagan, Bernardino Ghetti, Alison M Goate, David M. Holtzman, William E. Klunk, Eric McDade, Daniel S. Marcus, Ralph Martins, Colin L. Masters, Richard P. Mayeux, Angela Oliver, Kimberly Quaid, John M. Ringman, Martin N. Rossor, Stephen Salloway & 7 others Peter R. Schofield, Natalie J Selsor, Reisa A Sperling, Michael W. Weiner, Chengjie Xiong, Krista L Moulder, Virginia D Buckles

Research output: Contribution to journalArticle

Abstract

The Dominantly Inherited Alzheimer Network (DIAN) is a collaborative effort of international Alzheimer disease (AD) centers that are conducting a multifaceted prospective biomarker study in individuals at-risk for autosomal dominant AD (ADAD). DIAN collects comprehensive information and tissue in accordance with standard protocols from asymptomatic and symptomatic ADAD mutation carriers and their non-carrier family members to determine the pathochronology of clinical, cognitive, neuroimaging, and fluid biomarkers of AD. This article describes the structure, implementation, and underlying principles of DIAN, as well as the demographic features of the initial DIAN cohort.

Original languageEnglish
Pages (from-to)975-984
Number of pages10
JournalClinical investigation
Volume2
Issue number10
DOIs
Publication statusPublished - 1 Oct 2012
Externally publishedYes

Keywords

  • Journal Article

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    Morris, J. C., Aisen, P. S., Bateman, R. J., Benzinger, T. L. S., Cairns, N. J., Fagan, A. M., ... Buckles, V. D. (2012). Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network. Clinical investigation, 2(10), 975-984. https://doi.org/10.4155/cli.12.93