Developing protein-based nanoparticles as versatile delivery systems for cancer therapy and imaging

Research output: Contribution to journalArticleResearchpeer-review

Abstract

In recent years, it has become apparent that cancer nanomedicine’s reliance on synthetic nanoparticles as drug delivery systems has resulted in limited clinical outcomes. This is mostly due to a poor understanding of their “bio-nano” interactions. Protein-based nanoparticles (PNPs) are rapidly emerging as versatile vehicles for the delivery of therapeutic and diagnostic agents, offering a potential alternative to synthetic nanoparticles. PNPs are abundant in nature, genetically and chemically modifiable, monodisperse, biocompatible, and biodegradable. To harness their full clinical potential, it is important for PNPs to be accurately designed and engineered. In this review, we outline the recent advancements and applications of PNPs in cancer nanomedicine. We also discuss the future directions for PNP research and what challenges must be overcome to ensure their translation into the clinic.

LanguageEnglish
Article number1329
Pages1-25
Number of pages25
JournalNanomaterials
Volume9
Issue number9
DOIs
Publication statusPublished - Sep 2019

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Nanoparticles
Proteins
Imaging techniques
Medical nanotechnology

Bibliographical note

Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Drug delivery
  • Nanomedicine
  • Cancer therapy
  • Cancer imaging
  • Virus-like particles
  • Protein-based nanoparticles
  • Synthetic biology

Cite this

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title = "Developing protein-based nanoparticles as versatile delivery systems for cancer therapy and imaging",
abstract = "In recent years, it has become apparent that cancer nanomedicine’s reliance on synthetic nanoparticles as drug delivery systems has resulted in limited clinical outcomes. This is mostly due to a poor understanding of their “bio-nano” interactions. Protein-based nanoparticles (PNPs) are rapidly emerging as versatile vehicles for the delivery of therapeutic and diagnostic agents, offering a potential alternative to synthetic nanoparticles. PNPs are abundant in nature, genetically and chemically modifiable, monodisperse, biocompatible, and biodegradable. To harness their full clinical potential, it is important for PNPs to be accurately designed and engineered. In this review, we outline the recent advancements and applications of PNPs in cancer nanomedicine. We also discuss the future directions for PNP research and what challenges must be overcome to ensure their translation into the clinic.",
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Developing protein-based nanoparticles as versatile delivery systems for cancer therapy and imaging. / Sandra, Febrina; Khaliq, Nisar Ul; Sunna, Anwar; Care, Andrew.

In: Nanomaterials, Vol. 9, No. 9, 1329, 09.2019, p. 1-25.

Research output: Contribution to journalArticleResearchpeer-review

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