TY - JOUR
T1 - Development and in-vitro evaluation of pH responsive polymeric nano hydrogel carrier system for gastro-protective delivery of naproxen sodium
AU - Sarfraz, Rai Muhammad
AU - Akram, Muhammad Rouf
AU - Ali, Muhammad Rizwan
AU - Mahmood, Asif
AU - Khan, Muhammad Usman
AU - Ahmad, Husnain
AU - Qaisar, Muhammad Naeem
N1 - Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2019
Y1 - 2019
N2 - Current research work was carried out for gastro-protective delivery of naproxen sodium. Polyethylene glycol-g-poly (methacrylic acid) nanogels was developed through free radical polymerization technique. Formulation was characterized for swelling behaviour, entrapment efficiency, Fourier transform infrared (FTIR) spectroscopy, Differential scanning calorimetry (DSC), and Thermal Gravimetric Analysis (TGA), Powder X-ray diffraction (PXRD), Zeta size distribution, and Zeta potential measurements, and in vitro drug release. pH dependent swelling was observed with maximum drug release at higher pH. PXRD studies confirmed the conversion of loaded drug from crystalline to amorphous form while Zeta size measurement showed size reduction. On the basis of these results it was concluded that prepared nanogels proved an effective tool for gastro-protective delivery of naproxen sodium.
AB - Current research work was carried out for gastro-protective delivery of naproxen sodium. Polyethylene glycol-g-poly (methacrylic acid) nanogels was developed through free radical polymerization technique. Formulation was characterized for swelling behaviour, entrapment efficiency, Fourier transform infrared (FTIR) spectroscopy, Differential scanning calorimetry (DSC), and Thermal Gravimetric Analysis (TGA), Powder X-ray diffraction (PXRD), Zeta size distribution, and Zeta potential measurements, and in vitro drug release. pH dependent swelling was observed with maximum drug release at higher pH. PXRD studies confirmed the conversion of loaded drug from crystalline to amorphous form while Zeta size measurement showed size reduction. On the basis of these results it was concluded that prepared nanogels proved an effective tool for gastro-protective delivery of naproxen sodium.
UR - http://www.scopus.com/inward/record.url?scp=85078825426&partnerID=8YFLogxK
U2 - 10.1155/2019/6090965
DO - 10.1155/2019/6090965
M3 - Article
AN - SCOPUS:85078825426
SN - 0730-6679
VL - 2019
SP - 1
EP - 13
JO - Advances in Polymer Technology
JF - Advances in Polymer Technology
M1 - 6090965
ER -