Development of 3D antibiotic-eluting bioresorbable scaffold with attenuating envelopes

Benjamin Chow*, Alex Baume, Peter Lok, Jake Cao, Nick Coleman, Andrew Ruys, Philip Boughton

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Thick section 3D bioresorbable scaffolds are proposed as a potential alternative to biologic skin grafts and supportive fillers for non-healing chronic wound ulcers. Synthetic bioresorbable scaffolds avoid human and animal derived contamination risks, provide feasible shelf life, availability and cost, and act as a consistent platform for localized drug elution. A bioresorbable polyester-based scaffold (Infilon™) was investigated as a drug delivery vehicle for chloramphenicol antibiotic (CAP) combined with a bioactive envelope. The effect of varying envelope protocols on antibiotic elution profile and antimicrobial potency on scaffolds were analysed. The maximum antibiotic loading efficiency of the scaffold was 10.18% w/w. The antibiotic elution profile showed that the burst phase lasted one hour subsequent to a sustained phase approaching near asymptotic release. Envelope permutations of bulk metallic glass (BMG) and Bioglass 45S5 reduced the total amount of antibiotic released by 1 to 1.8 mg while the polyethylene oxide envelope extended the burst phase to 2 hours. CAP loaded scaffolds demonstrated antimicrobial effectiveness for 24 hours. Results show potential for the Infilon™ scaffold to be used as a platform for localized antibiotic delivery. Delivery profiles can be enhanced with additional BMG or Bioglass envelopes. This approach has opportunity to provide a synergistic coupling of antimicrobial action and the harbouring of granular tissue subsequent to final wound healing.

Original languageEnglish
Pages (from-to)55-62
Number of pages8
JournalJournal of Biomimetics, Biomaterials, and Tissue Engineering
Volume15
DOIs
Publication statusPublished - Oct 2012
Externally publishedYes

Keywords

  • 3D scaffolds
  • Antibiotic elution profile
  • Antimicrobial
  • Bioglass 45S5
  • Bulk metallic glass
  • Infilon™
  • Loading efficiency
  • Polyethylene oxide
  • Scaffold envelope

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