Abstract
Thick section 3D bioresorbable scaffolds are proposed as a potential alternative to biologic skin grafts and supportive fillers for non-healing chronic wound ulcers. Synthetic bioresorbable scaffolds avoid human and animal derived contamination risks, provide feasible shelf life, availability and cost, and act as a consistent platform for localized drug elution. A bioresorbable polyester-based scaffold (Infilon™) was investigated as a drug delivery vehicle for chloramphenicol antibiotic (CAP) combined with a bioactive envelope. The effect of varying envelope protocols on antibiotic elution profile and antimicrobial potency on scaffolds were analysed. The maximum antibiotic loading efficiency of the scaffold was 10.18% w/w. The antibiotic elution profile showed that the burst phase lasted one hour subsequent to a sustained phase approaching near asymptotic release. Envelope permutations of bulk metallic glass (BMG) and Bioglass 45S5 reduced the total amount of antibiotic released by 1 to 1.8 mg while the polyethylene oxide envelope extended the burst phase to 2 hours. CAP loaded scaffolds demonstrated antimicrobial effectiveness for 24 hours. Results show potential for the Infilon™ scaffold to be used as a platform for localized antibiotic delivery. Delivery profiles can be enhanced with additional BMG or Bioglass envelopes. This approach has opportunity to provide a synergistic coupling of antimicrobial action and the harbouring of granular tissue subsequent to final wound healing.
Original language | English |
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Pages (from-to) | 55-62 |
Number of pages | 8 |
Journal | Journal of Biomimetics, Biomaterials, and Tissue Engineering |
Volume | 15 |
DOIs | |
Publication status | Published - Oct 2012 |
Externally published | Yes |
Keywords
- 3D scaffolds
- Antibiotic elution profile
- Antimicrobial
- Bioglass 45S5
- Bulk metallic glass
- Infilon™
- Loading efficiency
- Polyethylene oxide
- Scaffold envelope