Development of a new dyspepsia impact scale

the nepean dyspepsia index

N J Talley, M Haque, J W Wyeth, N H Stace, G N Tytgat, Vincenzo Stanghellini, G. Holtmann, Marleen Verlinden, Mike Jones

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

BACKGROUND: There is not at present a suitable disease-specific health-related quality of life instrument for uninvestigated dyspepsia and functional (non-ulcer) dyspepsia.

AIM: To develop a new multi-dimensional disease-specific instrument.

METHODS: The Nepean Dyspepsia Index (NDI) was designed to measure impairment of a subject's ability to engage in relevant aspects of their life and also their enjoyment of these aspects; in addition, the individual importance of each aspect is assessed. A 42-item quality of life measure was developed and tested, both in out-patients presenting to general practice with upper gastrointestinal complaints (n = 113) and in a randomly chosen population-based sample (n = 347).

RESULTS: Adequate face and content validity was documented by an expert panel. Factor analysis identified four clinically relevant subscales: interference with activities of daily living, work, enjoyment of life and emotional well-being; lack of knowledge and control over the illness; disturbance to eating or drinking; and disturbance to sleep because of dyspepsia. These scales had high internal consistency. Both symptoms and the quality of life scores discriminated dyspepsia from health.

CONCLUSION: The Nepean Dyspepsia Index is a reliable and valid disease-specific index for dyspepsia, measuring symptoms and health-related quality of life.

Original languageEnglish
Pages (from-to)225-235
Number of pages11
JournalAlimentary Pharmacology and Therapeutics
Volume13
Issue number2
DOIs
Publication statusPublished - Feb 1999
Externally publishedYes

Keywords

  • Adult
  • Aged
  • Dyspepsia
  • Female
  • Humans
  • Male
  • Middle Aged
  • Quality of Life
  • Journal Article
  • Research Support, Non-U.S. Gov't

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