Development of a Point-of-Care diagnostic smart sensing system to detect creatinine levels

Sumedha Prabhu; Chinthaka Gooneratne; Ky Anh Hoang; Subhas Mukhopadhyay

doi:10.1109/MWSCAS48704.2020.9184441

Development of a Point-of-Care diagnostic smart sensing system to detect creatinine levels

Sumedha Prabhu, Chinthaka Gooneratne, Ky Anh Hoang, Subhas Mukhopadhyay

School of Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

7 Citations (Scopus)

Abstract

In this work, a non-invasive Electrochemical Impedance Spectroscopy (EIS) Point-of-Care (PoC) diagnostic device to detect the creatinine concentration from the serum is presented. A Micro-Electro-Mechanical Systems (MEMS) sensor was used for measuring the electrochemical properties of Sample Under Test (SUT). The EIS technique was utilised along with the sensor to find out different creatinine concentrations in heat-inactivated serum samples. Creatinine specific Molecularly Imprinted Polymerization (MIP)-coated sensor was used to measure the levels of creatinine followed by the development of a LoRaWAN-based PoC diagnostic device. In the next step, the results obtained from the diagnostic device were cross-verified by using standard Creatinine Colorimetric Assay Kit. The results were found to be promising to further continue the research.

Original language	English
Title of host publication	2020 IEEE 63rd International Midwest Symposium on Circuits and Systems (MWSCAS)
Subtitle of host publication	on-line proceedings
Place of Publication	Piscataway, NJ
Publisher	Institute of Electrical and Electronics Engineers (IEEE)
Pages	77-80
Number of pages	4
ISBN (Electronic)	9781728180588, 9781538629161
ISBN (Print)	9781728180595
DOIs	https://doi.org/10.1109/MWSCAS48704.2020.9184441
Publication status	Published - 2020
Event	63rd IEEE International Midwest Symposium on Circuits and Systems, MWSCAS 2020 - Springfield, United States Duration: 9 Aug 2020 → 12 Aug 2020

Publication series

Name
ISSN (Print)	1548-3746
ISSN (Electronic)	1558-3899

Conference

Conference	63rd IEEE International Midwest Symposium on Circuits and Systems, MWSCAS 2020
Country/Territory	United States
City	Springfield
Period	9/08/20 → 12/08/20

Keywords

Electrochemical Impedance Spectroscopy (EIS)
Point-of-Care (PoC)
Micro-Electro-Mechanical Systems (MEMS)
Molecularly Imprinted Polymerization (MIP)
Colorimetric Assay

Access to Document

10.1109/MWSCAS48704.2020.9184441

Cite this

Prabhu, S., Gooneratne, C., Hoang, K. A., & Mukhopadhyay, S. (2020). Development of a Point-of-Care diagnostic smart sensing system to detect creatinine levels. In 2020 IEEE 63rd International Midwest Symposium on Circuits and Systems (MWSCAS): on-line proceedings (pp. 77-80). Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/MWSCAS48704.2020.9184441

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title = "Development of a Point-of-Care diagnostic smart sensing system to detect creatinine levels",

abstract = "In this work, a non-invasive Electrochemical Impedance Spectroscopy (EIS) Point-of-Care (PoC) diagnostic device to detect the creatinine concentration from the serum is presented. A Micro-Electro-Mechanical Systems (MEMS) sensor was used for measuring the electrochemical properties of Sample Under Test (SUT). The EIS technique was utilised along with the sensor to find out different creatinine concentrations in heat-inactivated serum samples. Creatinine specific Molecularly Imprinted Polymerization (MIP)-coated sensor was used to measure the levels of creatinine followed by the development of a LoRaWAN-based PoC diagnostic device. In the next step, the results obtained from the diagnostic device were cross-verified by using standard Creatinine Colorimetric Assay Kit. The results were found to be promising to further continue the research.",

keywords = "Electrochemical Impedance Spectroscopy (EIS), Point-of-Care (PoC), Micro-Electro-Mechanical Systems (MEMS), Molecularly Imprinted Polymerization (MIP), Colorimetric Assay",

author = "Sumedha Prabhu and Chinthaka Gooneratne and Hoang, {Ky Anh} and Subhas Mukhopadhyay",

year = "2020",

doi = "10.1109/MWSCAS48704.2020.9184441",

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booktitle = "2020 IEEE 63rd International Midwest Symposium on Circuits and Systems (MWSCAS)",

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Prabhu, S, Gooneratne, C, Hoang, KA & Mukhopadhyay, S 2020, Development of a Point-of-Care diagnostic smart sensing system to detect creatinine levels. in 2020 IEEE 63rd International Midwest Symposium on Circuits and Systems (MWSCAS): on-line proceedings. Institute of Electrical and Electronics Engineers (IEEE), Piscataway, NJ, pp. 77-80, 63rd IEEE International Midwest Symposium on Circuits and Systems, MWSCAS 2020, Springfield, United States, 9/08/20. https://doi.org/10.1109/MWSCAS48704.2020.9184441

Development of a Point-of-Care diagnostic smart sensing system to detect creatinine levels. / Prabhu, Sumedha; Gooneratne, Chinthaka; Hoang, Ky Anh et al.

2020 IEEE 63rd International Midwest Symposium on Circuits and Systems (MWSCAS): on-line proceedings. Piscataway, NJ : Institute of Electrical and Electronics Engineers (IEEE), 2020. p. 77-80.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

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PY - 2020

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Prabhu S, Gooneratne C, Hoang KA, Mukhopadhyay S. Development of a Point-of-Care diagnostic smart sensing system to detect creatinine levels. In 2020 IEEE 63rd International Midwest Symposium on Circuits and Systems (MWSCAS): on-line proceedings. Piscataway, NJ: Institute of Electrical and Electronics Engineers (IEEE). 2020. p. 77-80 https://doi.org/10.1109/MWSCAS48704.2020.9184441

Development of a Point-of-Care diagnostic smart sensing system to detect creatinine levels

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