Abstract
⁹⁰Y microspheres are important therapeutic radiopharmaceuticals used in the treatment of liver cancer through a process known as selective internal radiation therapy. SIR-spheres® is a radiopharmaceutical product that is comprised of ⁹⁰Y microspheres suspended in sterile, pyrogen-free water for injection into patients. It is necessary to establish for the SIR-spheres® production the capability of accurately measuring the activity of this product to a traceable national measurement standard. An activity standard for SIR-spheres® was developed from a standard for ⁹⁰Y solution, employing a highly quantifiable chemical digestion process. Calibration factors for the manufacturer's ionisation chambers were determined for 1 and 5 ml of the SIR-spheres® product placed in Wheaton vials, for both 34% and 44% of ⁹⁰Y microsphere concentration.
Original language | English |
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Pages (from-to) | 193-199 |
Number of pages | 7 |
Journal | Applied Radiation and Isotopes |
Volume | 63 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2005 |
Externally published | Yes |
Keywords
- ⁹⁰Y
- Activity measurement
- Chemical digestion
- Ionisation chamber calibration factor
- Microspheres; SIR-spheres®
- Solution