Development of activity standard for ⁹⁰Y microspheres

L. Mo; B. Avci; D. James; B. Simpson; W. M. Van Wyngaardt; J. T. Cessna; C. Baldock

doi:10.1016/j.apradiso.2005.02.002

Development of activity standard for ⁹⁰Y microspheres

L. Mo, B. Avci, D. James, B. Simpson, W. M. Van Wyngaardt, J. T. Cessna, C. Baldock

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

⁹⁰Y microspheres are important therapeutic radiopharmaceuticals used in the treatment of liver cancer through a process known as selective internal radiation therapy. SIR-spheres® is a radiopharmaceutical product that is comprised of ⁹⁰Y microspheres suspended in sterile, pyrogen-free water for injection into patients. It is necessary to establish for the SIR-spheres® production the capability of accurately measuring the activity of this product to a traceable national measurement standard. An activity standard for SIR-spheres® was developed from a standard for ⁹⁰Y solution, employing a highly quantifiable chemical digestion process. Calibration factors for the manufacturer's ionisation chambers were determined for 1 and 5 ml of the SIR-spheres® product placed in Wheaton vials, for both 34% and 44% of ⁹⁰Y microsphere concentration.

Original language	English
Pages (from-to)	193-199
Number of pages	7
Journal	Applied Radiation and Isotopes
Volume	63
Issue number	2
DOIs	https://doi.org/10.1016/j.apradiso.2005.02.002
Publication status	Published - 2005
Externally published	Yes

Keywords

⁹⁰Y
Activity measurement
Chemical digestion
Ionisation chamber calibration factor
Microspheres; SIR-spheres®
Solution

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10.1016/j.apradiso.2005.02.002

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title = "Development of activity standard for ⁹⁰Y microspheres",

abstract = "⁹⁰Y microspheres are important therapeutic radiopharmaceuticals used in the treatment of liver cancer through a process known as selective internal radiation therapy. SIR-spheres{\textregistered} is a radiopharmaceutical product that is comprised of ⁹⁰Y microspheres suspended in sterile, pyrogen-free water for injection into patients. It is necessary to establish for the SIR-spheres{\textregistered} production the capability of accurately measuring the activity of this product to a traceable national measurement standard. An activity standard for SIR-spheres{\textregistered} was developed from a standard for ⁹⁰Y solution, employing a highly quantifiable chemical digestion process. Calibration factors for the manufacturer's ionisation chambers were determined for 1 and 5 ml of the SIR-spheres{\textregistered} product placed in Wheaton vials, for both 34% and 44% of ⁹⁰Y microsphere concentration.",

keywords = "⁹⁰Y, Activity measurement, Chemical digestion, Ionisation chamber calibration factor, Microspheres; SIR-spheres{\textregistered}, Solution",

author = "L. Mo and B. Avci and D. James and B. Simpson and {Van Wyngaardt}, {W. M.} and Cessna, {J. T.} and C. Baldock",

year = "2005",

doi = "10.1016/j.apradiso.2005.02.002",

language = "English",

volume = "63",

pages = "193--199",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier",

number = "2",

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TY - JOUR

T1 - Development of activity standard for ⁹⁰Y microspheres

AU - Mo, L.

AU - Avci, B.

AU - James, D.

AU - Simpson, B.

AU - Van Wyngaardt, W. M.

AU - Cessna, J. T.

AU - Baldock, C.

PY - 2005

Y1 - 2005

N2 - ⁹⁰Y microspheres are important therapeutic radiopharmaceuticals used in the treatment of liver cancer through a process known as selective internal radiation therapy. SIR-spheres® is a radiopharmaceutical product that is comprised of ⁹⁰Y microspheres suspended in sterile, pyrogen-free water for injection into patients. It is necessary to establish for the SIR-spheres® production the capability of accurately measuring the activity of this product to a traceable national measurement standard. An activity standard for SIR-spheres® was developed from a standard for ⁹⁰Y solution, employing a highly quantifiable chemical digestion process. Calibration factors for the manufacturer's ionisation chambers were determined for 1 and 5 ml of the SIR-spheres® product placed in Wheaton vials, for both 34% and 44% of ⁹⁰Y microsphere concentration.

AB - ⁹⁰Y microspheres are important therapeutic radiopharmaceuticals used in the treatment of liver cancer through a process known as selective internal radiation therapy. SIR-spheres® is a radiopharmaceutical product that is comprised of ⁹⁰Y microspheres suspended in sterile, pyrogen-free water for injection into patients. It is necessary to establish for the SIR-spheres® production the capability of accurately measuring the activity of this product to a traceable national measurement standard. An activity standard for SIR-spheres® was developed from a standard for ⁹⁰Y solution, employing a highly quantifiable chemical digestion process. Calibration factors for the manufacturer's ionisation chambers were determined for 1 and 5 ml of the SIR-spheres® product placed in Wheaton vials, for both 34% and 44% of ⁹⁰Y microsphere concentration.

KW - ⁹⁰Y

KW - Activity measurement

KW - Chemical digestion

KW - Ionisation chamber calibration factor

KW - Microspheres; SIR-spheres®

KW - Solution

U2 - 10.1016/j.apradiso.2005.02.002

DO - 10.1016/j.apradiso.2005.02.002

M3 - Article

C2 - 15963429

SN - 0969-8043

VL - 63

SP - 193

EP - 199

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 2

ER -

Development of activity standard for ⁹⁰Y microspheres

Abstract

Keywords

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