Development of activity standard for ⁹⁰Y microspheres

L. Mo, B. Avci, D. James, B. Simpson, W. M. Van Wyngaardt, J. T. Cessna, C. Baldock

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21 Citations (Scopus)


⁹⁰Y microspheres are important therapeutic radiopharmaceuticals used in the treatment of liver cancer through a process known as selective internal radiation therapy. SIR-spheres® is a radiopharmaceutical product that is comprised of ⁹⁰Y microspheres suspended in sterile, pyrogen-free water for injection into patients. It is necessary to establish for the SIR-spheres® production the capability of accurately measuring the activity of this product to a traceable national measurement standard. An activity standard for SIR-spheres® was developed from a standard for ⁹⁰Y solution, employing a highly quantifiable chemical digestion process. Calibration factors for the manufacturer's ionisation chambers were determined for 1 and 5 ml of the SIR-spheres® product placed in Wheaton vials, for both 34% and 44% of ⁹⁰Y microsphere concentration.
Original languageEnglish
Pages (from-to)193-199
Number of pages7
JournalApplied Radiation and Isotopes
Issue number2
Publication statusPublished - 2005
Externally publishedYes


  • ⁹⁰Y
  • Activity measurement
  • Chemical digestion
  • Ionisation chamber calibration factor
  • Microspheres; SIR-spheres®
  • Solution


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