Development of modified apple polysaccharide capped silver nanoparticles loaded with mesalamine for effective treatment of ulcerative colitis

Gurmandeep Kaur, Sachin Kumar Singh*, Rajesh Kumar, Bimlesh Kumar, Yogita Kumari, Monica Gulati, Narendra Kumar Pandey, K. Gowthamarajan, Dipanjoy Ghosh, A. Clarisse, Sheetu Wadhwa, Meenu Mehta, Saurabh Satija, Kamal Dua, Harish Dureja, Saurabh Gupta, Pankaj Kumar Singh, Bhupinder Kapoor, Nitin Chitranshi, Ankit KumarOmji Porwal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The objective of study was to develop modified apple polysaccharide (MAP) based silver nanoparticles (AgNPs) loaded with mesalamine (MES) for effective treatment of ulcerative colitis in acetic acid induced rat model. AgNPs were prepared by reducing silver nitrate using MAP solution. The size and zeta potential of AgNPs was 89 ± 3 nm and −16.3 ± 1.54 mV and AgNPs loaded with MES (AgNPs-MES) was 101 ± 9 nm and −14.27 ± 2.16 mV. The dissolution study revealed about 54% drug release after 5 h indicating release of drug at the colonic site. The in vivo study was carried out on acetic acid induced ulcerative colitis rats and efficacy of treatment was assessed through evaluation of disease activity index and level of antioxidants as well as tumor necrosis factor-α after 7th and 14th day of induction of colitis. Histopathological evaluation of colonic tissue was also carried out. The results revealed that AgNPs-MES (high dose) provided better therapeutic efficacy for the treatment of UC as compared to its low dose, MES alone, MES-MAP, AgNPs alone and MAP alone. It was concluded that MAP based AgNPs loaded with MES were successfully formulated and found to be effective in treating ulcerative colitis.

Original languageEnglish
Article number101980
Pages (from-to)1-10
Number of pages10
JournalJournal of Drug Delivery Science and Technology
Volume60
DOIs
Publication statusPublished - Dec 2020

Keywords

  • Mesalamine
  • Modified apple polysaccharide
  • Silver nanoparticles
  • Ulcerative colitis

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