Development of molecular imprinted polymer interdigital sensor for C-terminal telopeptide of type I collagen

Nasrin Afsarimanesh*, M. E E Alahi, Subhas Mukhopadhyay, Marlena Kruger, Pak Lam Yu

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

3 Citations (Scopus)

Abstract

This paper presents a label-free and non-invasive technique for selective detection of C-terminal telopeptide type I collagen (CTx-I) by employing Electrochemical Impedance Spectroscopy to measure sample impedance. Molecular imprinted polymer, containing artificial recognition sites for CTx-was prepared by precipitation polymerization using CTx-I peptide as a template, methacrylic acid as a functional monomer and ethylene glycol methacrylate as the cross-linker. A high penetration depth planar interdigital sensor was functionalized by a self-assembled monolayer along with the synthesized MIP. Different concentrations of CTx-I sample solutions were tested using the proposed sensing system. High-Performance Liquid chromatography diode array system was used to validate the results.

Original languageEnglish
Title of host publication2016 10th International Conference on Sensing Technology, ICST 2016
Place of PublicationPiscataway, NJ
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages1-5
Number of pages5
ISBN (Electronic)9781509007967
DOIs
Publication statusPublished - 22 Dec 2016
Event10th International Conference on Sensing Technology, ICST 2016 - Nanjing, China
Duration: 11 Nov 201613 Nov 2016

Other

Other10th International Conference on Sensing Technology, ICST 2016
CountryChina
CityNanjing
Period11/11/1613/11/16

Keywords

  • bone turnover markers
  • electrochemical impedance spectroscopy
  • interdigital sensor
  • molecular imprinted polymers

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