TY - JOUR
T1 - Diagnosis and treatment of Chiari malformation and syringomyelia in adults
T2 - international consensus document
AU - Ciaramitaro, Palma
AU - Massimi, Luca
AU - Bertuccio, Alessandro
AU - Solari, Alessandra
AU - Farinotti, Mariangela
AU - Peretta, Paola
AU - Saletti, Veronica
AU - Chiapparini, Luisa
AU - Barbanera, Andrea
AU - Garbossa, Diego
AU - Bolognese, Paolo
AU - Brodbelt, Andrew
AU - Celada, Carlo
AU - Cocito, Dario
AU - Curone, Marcella
AU - Devigili, Grazia
AU - Erbetta, Alessandra
AU - Ferraris, Marilena
AU - Furlanetto, Marika
AU - Gilanton, Mado
AU - Jallo, George
AU - Karadjova, Marieta
AU - Klekamp, Jorg
AU - Massaro, Fulvio
AU - Morar, Sylvia
AU - Parker, Fabrice
AU - Perrini, Paolo
AU - Poca, Maria Antonia
AU - Sahuquillo, Juan
AU - Stoodley, Marcus
AU - Talamonti, Giuseppe
AU - Triulzi, Fabio
AU - Valentini, Maria Consuelo
AU - Visocchi, Massimiliano
AU - Valentini, Laura
AU - On behalf of the International Experts Jury of the Chiari Syringomyelia Consensus Conference, Milan, November 11-13, 2019
N1 - A correction exists for this article, and has been included in the final published version.
PY - 2022/2
Y1 - 2022/2
N2 - Background Syringomyelia and Chiari malformation are classified as rare diseases on Orphanet, but international guidelines on diagnostic criteria and case definition are missing. Aim of the study: to reach a consensus among international experts on controversial issues in diagnosis and treatment of Chiari 1 malformation and syringomyelia in adults. Methods A multidisciplinary panel of the Chiari and Syringomyelia Consortium (4 neurosurgeons, 2 neurologists, 1 neuroradiologist, 1 pediatric neurologist) appointed an international Jury of experts to elaborate a consensus document. After an evidence-based review and further discussions, 63 draft statements grouped in 4 domains (definition and classification/planning/surgery/isolated syringomyelia) were formulated. A Jury of 32 experts in the field of diagnosis and treatment of Chiari and syringomyelia and patient representatives were invited to take part in a three-round Delphi process. The Jury received a structured questionnaire containing the 63 statements, each to be voted on a 4-point Likert-type scale and commented. Statements with agreement <75% were revised and entered round 2. Round 3 was face-to-face, during the Chiari Consensus Conference (Milan, November 2019). Results Thirty-one out of 32 Jury members (6 neurologists, 4 neuroradiologists, 19 neurosurgeons, and 2 patient association representatives) participated in the consensus. After round 2, a consensus was reached on 57/63 statements (90.5%). The six difficult statements were revised and voted in round 3, and the whole set of statements was further discussed and approved. Conclusions The consensus document consists of 63 statements which benefited from expert discussion and fine-tuning, serving clinicians and researchers following adults with Chiari and syringomyelia.
AB - Background Syringomyelia and Chiari malformation are classified as rare diseases on Orphanet, but international guidelines on diagnostic criteria and case definition are missing. Aim of the study: to reach a consensus among international experts on controversial issues in diagnosis and treatment of Chiari 1 malformation and syringomyelia in adults. Methods A multidisciplinary panel of the Chiari and Syringomyelia Consortium (4 neurosurgeons, 2 neurologists, 1 neuroradiologist, 1 pediatric neurologist) appointed an international Jury of experts to elaborate a consensus document. After an evidence-based review and further discussions, 63 draft statements grouped in 4 domains (definition and classification/planning/surgery/isolated syringomyelia) were formulated. A Jury of 32 experts in the field of diagnosis and treatment of Chiari and syringomyelia and patient representatives were invited to take part in a three-round Delphi process. The Jury received a structured questionnaire containing the 63 statements, each to be voted on a 4-point Likert-type scale and commented. Statements with agreement <75% were revised and entered round 2. Round 3 was face-to-face, during the Chiari Consensus Conference (Milan, November 2019). Results Thirty-one out of 32 Jury members (6 neurologists, 4 neuroradiologists, 19 neurosurgeons, and 2 patient association representatives) participated in the consensus. After round 2, a consensus was reached on 57/63 statements (90.5%). The six difficult statements were revised and voted in round 3, and the whole set of statements was further discussed and approved. Conclusions The consensus document consists of 63 statements which benefited from expert discussion and fine-tuning, serving clinicians and researchers following adults with Chiari and syringomyelia.
KW - Chiari malformation
KW - Syringomyelia
KW - Adults
KW - Consensus
KW - Classification
KW - Surgery
UR - https://www.scopus.com/pages/publications/85107910778
UR - http://www.scopus.com/inward/record.url?scp=85119362219&partnerID=8YFLogxK
UR - https://doi.org/10.1007/s10072-021-05724-y
U2 - 10.1007/s10072-021-05347-3
DO - 10.1007/s10072-021-05347-3
M3 - Article
C2 - 34786631
AN - SCOPUS:85107910778
SN - 1590-1874
VL - 43
SP - 1327
EP - 1342
JO - Neurological Sciences
JF - Neurological Sciences
IS - 2
ER -