Diagnosis of breast implant associated anaplastic large cell lymphoma by analysis of cytokines in peri-implant seromas

Honghua Hu; Elena Shklovskaya; Anand Deva; Haiying Xu; Kelly Fan; Kristen Brosamer; Richard Willson; Imran Khan; Mithun Sinha; Marshall E. Kadin

doi:10.1002/ajh.27055

Diagnosis of breast implant associated anaplastic large cell lymphoma by analysis of cytokines in peri-implant seromas

Honghua Hu, Elena Shklovskaya, Anand Deva, Haiying Xu, Kelly Fan, Kristen Brosamer, Richard Willson, Imran Khan, Mithun Sinha, Marshall E. Kadin^*

^*Corresponding author for this work

Macquarie Medical School

Research output: Contribution to journal › Letter › peer-review

2 Citations (Scopus)

Abstract

More than 1300 women with breast implants have developed an anaplastic large cell lymphoma (ALCL) in fluid (seroma) around their implant. More often, seromas are due to benign causes, for example, capsule contracture, leakage, or trauma. Our report in American Journal of Hematology identified several cytokines (IL-9, IL-10, IL-13) as significantly elevated only in seromas due to ALCL. We further showed that the most robust biomarker, IL-10, could be detected by a lateral flow assay (similar to COVID detection) within minutes allowing physicians to quickly plan management, eliminate or reduce costly testing and patient time away from family. Early detection of ALCL in seromas before infiltration may avoid need for cytotoxic or immunotherapy and is possibly life-saving.

Original language	English
Pages (from-to)	E312-E314
Number of pages	3
Journal	American Journal of Hematology
Volume	98
Issue number	11
Early online date	30 Aug 2023
DOIs	https://doi.org/10.1002/ajh.27055
Publication status	Published - Nov 2023

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title = "Diagnosis of breast implant associated anaplastic large cell lymphoma by analysis of cytokines in peri-implant seromas",

abstract = "More than 1300 women with breast implants have developed an anaplastic large cell lymphoma (ALCL) in fluid (seroma) around their implant. More often, seromas are due to benign causes, for example, capsule contracture, leakage, or trauma. Our report in American Journal of Hematology identified several cytokines (IL-9, IL-10, IL-13) as significantly elevated only in seromas due to ALCL. We further showed that the most robust biomarker, IL-10, could be detected by a lateral flow assay (similar to COVID detection) within minutes allowing physicians to quickly plan management, eliminate or reduce costly testing and patient time away from family. Early detection of ALCL in seromas before infiltration may avoid need for cytotoxic or immunotherapy and is possibly life-saving.",

author = "Honghua Hu and Elena Shklovskaya and Anand Deva and Haiying Xu and Kelly Fan and Kristen Brosamer and Richard Willson and Imran Khan and Mithun Sinha and Kadin, {Marshall E.}",

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T1 - Diagnosis of breast implant associated anaplastic large cell lymphoma by analysis of cytokines in peri-implant seromas

AU - Hu, Honghua

AU - Shklovskaya, Elena

AU - Deva, Anand

AU - Xu, Haiying

AU - Fan, Kelly

AU - Brosamer, Kristen

AU - Willson, Richard

AU - Khan, Imran

AU - Sinha, Mithun

AU - Kadin, Marshall E.

PY - 2023/11

Y1 - 2023/11

N2 - More than 1300 women with breast implants have developed an anaplastic large cell lymphoma (ALCL) in fluid (seroma) around their implant. More often, seromas are due to benign causes, for example, capsule contracture, leakage, or trauma. Our report in American Journal of Hematology identified several cytokines (IL-9, IL-10, IL-13) as significantly elevated only in seromas due to ALCL. We further showed that the most robust biomarker, IL-10, could be detected by a lateral flow assay (similar to COVID detection) within minutes allowing physicians to quickly plan management, eliminate or reduce costly testing and patient time away from family. Early detection of ALCL in seromas before infiltration may avoid need for cytotoxic or immunotherapy and is possibly life-saving.

AB - More than 1300 women with breast implants have developed an anaplastic large cell lymphoma (ALCL) in fluid (seroma) around their implant. More often, seromas are due to benign causes, for example, capsule contracture, leakage, or trauma. Our report in American Journal of Hematology identified several cytokines (IL-9, IL-10, IL-13) as significantly elevated only in seromas due to ALCL. We further showed that the most robust biomarker, IL-10, could be detected by a lateral flow assay (similar to COVID detection) within minutes allowing physicians to quickly plan management, eliminate or reduce costly testing and patient time away from family. Early detection of ALCL in seromas before infiltration may avoid need for cytotoxic or immunotherapy and is possibly life-saving.

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U2 - 10.1002/ajh.27055

DO - 10.1002/ajh.27055

M3 - Letter

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SP - E312-E314

JO - American Journal of Hematology

JF - American Journal of Hematology

IS - 11

ER -

Diagnosis of breast implant associated anaplastic large cell lymphoma by analysis of cytokines in peri-implant seromas

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