Dialysis cells for controlled DNA

drug binding studies

K. J. Sanders*, H. Wiles, A. Rodger

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An efficient small volume accurate dialysis system has been designed, built and tested for proflavine binding to DNA based upon the side by side design used in the Franz diffusion cell. In a typical experiment 3 cm3 of DNA solution is added to one side and 3 cm3 of ligand to the other with a dialysis membrane between the two sides of 1 cm in diameter, thereby minimizing the area of dialysis membrane that the solutions are in contact with.

Original languageEnglish
Pages (from-to)852-854
Number of pages3
JournalAnalyst
Volume126
Issue number6
DOIs
Publication statusPublished - 2001
Externally publishedYes

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