Diastereospecific fluorination of substituted azepanes

Alpesh Ramanlal Patel, Fei Liu*

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Fluorination of bioactive compounds is an important step in drug discovery and development. Fluorination has been extensively studied in acyclic systems, carbocycles, and fused heterocycles. However, there is no report on fluorination of azepanes. As azepanes are components of many biologically active substances and natural products. We herein present the first fluorination examples of substituted azepanes. Fluoroazepanes were prepared by deoxyfluorination diastereospecifically in excellent yields. The absolute configuration at the fluorination site was unambiguously assigned by 2D NMR spectroscopy.

Original languageEnglish
Pages (from-to)744-752
Number of pages9
JournalTetrahedron
Volume69
Issue number2
DOIs
Publication statusPublished - 14 Jan 2013

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