Dietary intake of animal-based products and likelihood of follicular lymphoma and survival: a population-based family case-control study

Michael K. Odutola, Marina T. van Leeuwen, Julie K. Bassett, Fiona Bruinsma, Jennifer Turner, John F. Seymour, Henry Miles Prince, Samuel T. Milliken, Mark Hertzberg, Fernando Roncolato, Stephen S. Opat, Robert Lindeman, Campbell Tiley, Judith Trotman, Emma Verner, Michael Harvey, Craig R. Underhill, Geza Benke, Graham G. Giles, Claire M. Vajdic*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Background: The association between dietary intake of foods of animal origin and follicular lymphoma (FL) risk and survival is uncertain. In this study, we examined the relationship between dietary intake of dairy foods and fats, meat, fish and seafoods, and the likelihood of FL and survival. Methods: We conducted a population-based family case-control study in Australia between 2011 and 2016 and included 710 cases, 303 siblings and 186 spouse/partner controls. We assessed dietary intake of animal products prior to diagnosis (the year before last) using a structured food frequency questionnaire and followed-up cases over a median of 6.9 years using record linkage to national death data. We examined associations with the likelihood of FL using logistic regression and used Cox regression to assess association with all-cause and FL-specific mortality among cases. Results: We observed an increased likelihood of FL with increasing daily quantity of oily fish consumption in the year before last (highest category OR = 1.96, CI = 1.02–3.77; p-trend 0.06) among cases and sibling controls, but no associations with spouse/partner controls. We found no association between the likelihood of FL and the consumption of other types of fish or seafood, meats or dairy foods and fats. In FL cases, we found no association between meat or oily fish intake and all-cause or FL-specific mortality. Conclusion: Our study showed suggestive evidence of a positive association between oily fish intake and the likelihood of FL, but findings varied by control type. Further investigation of the potential role of environmental contaminants in oily fish on FL etiology is warranted.

Original languageEnglish
Article number1048301
Pages (from-to)1-14
Number of pages14
JournalFrontiers in Nutrition
Volume9
DOIs
Publication statusPublished - 4 Jan 2023

Bibliographical note

Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • animal product
  • fish
  • follicular lymphoma
  • risk
  • survival

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