Dietary saturated fat promotes omega-3 polyunsaturated fatty acid incorporation into human plasma and erythrocytes

C. B. Dias, L. G. Wood, M. L. Garg

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review


Research in animal models suggests that dietary saturated fat (SFA) enhances omega-3 polyunsaturated fatty acids (n-3PUFA) incorporation in membranes and tissue cells, when compared to dietary omega-6 polyunsaturated fat (n-6PUFA). N-6PUFA are known to compete with n-3PUFA for the same enzymes in their metabolic pathway. Therefore, we investigated blood lipid levels and n-3PUFA incorporation into plasma and erythrocytes following dietary supplementation with n-3PUFA [2.4g eicosapentaenoic acid (EPA): docosahexaenoic acid (DHA) daily], combined with either a high SFA diet or a high n-6PUFA diet. This was a randomized, dietary intervention trial, in parallel design involving 25 healthy adults aged 18 to 65 years. Blood samples were collected after an overnight fast at baseline and after 6 weeks of dietary intervention. A significantly higher increase in n-3PUFA into plasma and erythrocyte lipids was observed after the consumption of the SFA diet when compared with the n-6PUFA diet (P=0.017 and P=0.006, respectively). The SFA diet also caused an increase in total (P=0.021) and low density lipoprotein (LDL) cholesterol (P=0.011). Thus, n-3PUFA supplementation appears to be more effective in increasing tissue n-3PUFA levels when the background diet is rich in SFA rather than n-6PUFA, despite increase in total and LDL cholesterol levels.
Original languageEnglish
Title of host publication107th AOCS Annual Meeting and Expo
Subtitle of host publicationHealth and Nutrition Interest Area Technical Program Abstracts
PublisherAmerican Oil Chemists' Society
Number of pages1
Publication statusPublished - 2016
Externally publishedYes
Event107th AOCS Annual Meeting - Salt Lake City, United States
Duration: 1 May 20164 May 2016


Conference107th AOCS Annual Meeting
Country/TerritoryUnited States
CitySalt Lake City


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