Dietary supplementation with curcumin reduce circulating levels of glycogen synthase kinase-3β and islet amyloid polypeptide in adults with high risk of type 2 diabetes and Alzheimer’s disease

Rohith N. Thota; Jessica I. Rosato; Cintia B. Dias; Tracy L. Burros; Ralph N. Martins; Manohar L. Garg

doi:10.3390/nu12041032

Dietary supplementation with curcumin reduce circulating levels of glycogen synthase kinase-3β and islet amyloid polypeptide in adults with high risk of type 2 diabetes and Alzheimer’s disease

Rohith N. Thota, Jessica I. Rosato, Cintia B. Dias, Tracy L. Burros, Ralph N. Martins, Manohar L. Garg

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Abstract

Dietary supplementation with curcumin has been previously reported to have beneficial effects in people with insulin resistance, type 2 diabetes (T2D) and Alzheimer’s disease (AD). This study investigated the effects of dietary supplementation with curcumin on key peptides implicated in insulin resistance in individuals with high risk of developing T2D. Plasma samples from participants recruited for a randomised controlled trial with curcumin (180 mg/day) for 12 weeks were analysed for circulating glycogen synthase kinase-3 β (GSK-3β) and islet amyloid polypeptide (IAPP). Outcome measures were determined using ELISA kits. The homeostasis model for assessment of insulin resistance (HOMA-IR) was measured as parameters of glycaemic control. Curcumin supplementation significantly reduced circulating GSK-3β (−2.4 ± 0.4 ng/mL vs. −0.3 ± 0.6, p = 0.0068) and IAPP (−2.0 ± 0.7 ng/mL vs. 0.4 ± 0.6, p = 0.0163) levels compared with the placebo group. Curcumin supplementation significantly reduced insulin resistance (−0.3 ± 0.1 vs. 0.01 ± 0.05, p = 0.0142) compared with placebo group. Dietary supplementation with curcumin reduced circulating levels of IAPP and GSK-3β, thus suggesting a novel mechanism through which curcumin could potentially be used for alleviating insulin resistance related markers for reducing the risk of T2D and AD.

Original language	English
Article number	1032
Pages (from-to)	1-11
Number of pages	11
Journal	Nutrients
Volume	12
Issue number	4
DOIs	https://doi.org/10.3390/nu12041032
Publication status	Published - Apr 2020

Bibliographical note

Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

curcumin
glycogen synthase kinase-3
insulin resistance
Islet amyloid polypeptide
type 2 diabetes mellitus
Glycogen synthase kinase-3
Insulin resistance
Curcumin
Type 2 diabetes mellitus

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title = "Dietary supplementation with curcumin reduce circulating levels of glycogen synthase kinase-3β and islet amyloid polypeptide in adults with high risk of type 2 diabetes and Alzheimer{\textquoteright}s disease",

abstract = "Dietary supplementation with curcumin has been previously reported to have beneficial effects in people with insulin resistance, type 2 diabetes (T2D) and Alzheimer{\textquoteright}s disease (AD). This study investigated the effects of dietary supplementation with curcumin on key peptides implicated in insulin resistance in individuals with high risk of developing T2D. Plasma samples from participants recruited for a randomised controlled trial with curcumin (180 mg/day) for 12 weeks were analysed for circulating glycogen synthase kinase-3 β (GSK-3β) and islet amyloid polypeptide (IAPP). Outcome measures were determined using ELISA kits. The homeostasis model for assessment of insulin resistance (HOMA-IR) was measured as parameters of glycaemic control. Curcumin supplementation significantly reduced circulating GSK-3β (−2.4 ± 0.4 ng/mL vs. −0.3 ± 0.6, p = 0.0068) and IAPP (−2.0 ± 0.7 ng/mL vs. 0.4 ± 0.6, p = 0.0163) levels compared with the placebo group. Curcumin supplementation significantly reduced insulin resistance (−0.3 ± 0.1 vs. 0.01 ± 0.05, p = 0.0142) compared with placebo group. Dietary supplementation with curcumin reduced circulating levels of IAPP and GSK-3β, thus suggesting a novel mechanism through which curcumin could potentially be used for alleviating insulin resistance related markers for reducing the risk of T2D and AD.",

keywords = "curcumin, glycogen synthase kinase-3, insulin resistance, Islet amyloid polypeptide, type 2 diabetes mellitus, Glycogen synthase kinase-3, Insulin resistance, Curcumin, Type 2 diabetes mellitus",

author = "Thota, {Rohith N.} and Rosato, {Jessica I.} and Dias, {Cintia B.} and Burros, {Tracy L.} and Martins, {Ralph N.} and Garg, {Manohar L.}",

note = "Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2020",

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doi = "10.3390/nu12041032",

language = "English",

volume = "12",

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Dietary supplementation with curcumin reduce circulating levels of glycogen synthase kinase-3β and islet amyloid polypeptide in adults with high risk of type 2 diabetes and Alzheimer’s disease. / Thota, Rohith N.; Rosato, Jessica I.; Dias, Cintia B. et al.

In: Nutrients, Vol. 12, No. 4, 1032, 04.2020, p. 1-11.

Research output: Contribution to journal › Article › peer-review

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AU - Dias, Cintia B.

AU - Burros, Tracy L.

AU - Martins, Ralph N.

AU - Garg, Manohar L.

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Dietary supplementation with curcumin reduce circulating levels of glycogen synthase kinase-3β and islet amyloid polypeptide in adults with high risk of type 2 diabetes and Alzheimer’s disease

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