Different effects of vascular aging on ischemic predisposition in healthy men and women

Mayooran Namasivayam; Carmel M. McEniery; Ian B. Wilkinson; Yasmin; John R. Cockroft; Barry J. McDonnell; Audrey Adji; Michael F. O'Rourke

doi:10.1161/HYPERTENSIONAHA.118.11642

Different effects of vascular aging on ischemic predisposition in healthy men and women

Mayooran Namasivayam, Carmel M. McEniery, Ian B. Wilkinson, Yasmin, John R. Cockroft, Barry J. McDonnell, Audrey Adji, Michael F. O'Rourke

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Invasive studies of the twentieth century showed the value of aortic pressure-time integrals as markers of myocardial oxygen demand and supply. More recent studies have used these concepts to evaluate the mechanisms of ischemic predisposition using noninvasive arterial tonometry in cardiology outpatients. We sought to evaluate the spectrum of myocardial oxygen demand and supply in a large cross-sectional community sample of healthy volunteers and identify the roles of age, sex, and wave reflection. Arterial tonometry was performed in 3682 healthy volunteers. Measures of systolic and diastolic pressure-time integrals and their ratio in addition to cardiac ejection duration were determined and analyzed by age and sex. Multiple regression analyses were performed to identify the mechanisms underlying observations, while controlling for confounders (heart rate, height, weight, and mean pressure). In a healthy cohort, older women more than men ( P<0.001) had unfavorable myocardial oxygen supply:demand ratios because of differing effects of vascular aging.

Original language	English
Pages (from-to)	1294-1300
Number of pages	7
Journal	Hypertension
Volume	72
Issue number	6
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.118.11642
Publication status	Published - 1 Dec 2018

Keywords

aging
hemodynamics
ischemia
vascular stiffness
women

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title = "Different effects of vascular aging on ischemic predisposition in healthy men and women",

abstract = "Invasive studies of the twentieth century showed the value of aortic pressure-time integrals as markers of myocardial oxygen demand and supply. More recent studies have used these concepts to evaluate the mechanisms of ischemic predisposition using noninvasive arterial tonometry in cardiology outpatients. We sought to evaluate the spectrum of myocardial oxygen demand and supply in a large cross-sectional community sample of healthy volunteers and identify the roles of age, sex, and wave reflection. Arterial tonometry was performed in 3682 healthy volunteers. Measures of systolic and diastolic pressure-time integrals and their ratio in addition to cardiac ejection duration were determined and analyzed by age and sex. Multiple regression analyses were performed to identify the mechanisms underlying observations, while controlling for confounders (heart rate, height, weight, and mean pressure). In a healthy cohort, older women more than men ( P<0.001) had unfavorable myocardial oxygen supply:demand ratios because of differing effects of vascular aging.",

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AU - McEniery, Carmel M.

AU - Wilkinson, Ian B.

AU - Yasmin,

AU - Cockroft, John R.

AU - McDonnell, Barry J.

AU - Adji, Audrey

AU - O'Rourke, Michael F.

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AB - Invasive studies of the twentieth century showed the value of aortic pressure-time integrals as markers of myocardial oxygen demand and supply. More recent studies have used these concepts to evaluate the mechanisms of ischemic predisposition using noninvasive arterial tonometry in cardiology outpatients. We sought to evaluate the spectrum of myocardial oxygen demand and supply in a large cross-sectional community sample of healthy volunteers and identify the roles of age, sex, and wave reflection. Arterial tonometry was performed in 3682 healthy volunteers. Measures of systolic and diastolic pressure-time integrals and their ratio in addition to cardiac ejection duration were determined and analyzed by age and sex. Multiple regression analyses were performed to identify the mechanisms underlying observations, while controlling for confounders (heart rate, height, weight, and mean pressure). In a healthy cohort, older women more than men ( P<0.001) had unfavorable myocardial oxygen supply:demand ratios because of differing effects of vascular aging.

KW - aging

KW - hemodynamics

KW - ischemia

KW - vascular stiffness

KW - women

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Different effects of vascular aging on ischemic predisposition in healthy men and women

Abstract

Keywords

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