Different levels of neuroprotection by two insulin-like growth factor-I splice variants

Michael Aperghis, Ian P. Johnson, John Cannon, Shi-Yu Yang, Geoffrey Goldspink*

*Corresponding author for this work

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

We compared the neuroprotective effects of a liver-type isoform of insulin-like growth factor-I (IGF-IEa) and its splice variant, mechano-growth factor (MGF), isolated from active skeletal muscle. cDNAs of these peptides were injected into the facial muscle of adult rats prior to facial nerve avulsion. This resulted in significant neuroprotection of 88% and 37%, respectively, of motoneurons compared to control plasmid and avulsion-only groups. MGF is markedly more effective than the liver-type, systemic IGF-I for motoneuron survival, suggesting a major role for the peripheral target in adult neuronal maintenance and survival.

Original languageEnglish
Pages (from-to)213-218
Number of pages6
JournalBrain Research
Volume1009
Issue number1-2
DOIs
Publication statusPublished - 29 May 2004
Externally publishedYes

Keywords

  • Adult
  • Avulsion
  • Facial nerve
  • IGF-I
  • MGF
  • Motoneuron
  • Motor systems and sensorimotor integration
  • Spinal cord and brainstem

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