Different levels of neuroprotection by two insulin-like growth factor-I splice variants

Michael Aperghis; Ian P. Johnson; John Cannon; Shi-Yu Yang; Geoffrey Goldspink

doi:10.1016/j.brainres.2004.02.049

Different levels of neuroprotection by two insulin-like growth factor-I splice variants

Michael Aperghis, Ian P. Johnson, John Cannon, Shi-Yu Yang, Geoffrey Goldspink^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

We compared the neuroprotective effects of a liver-type isoform of insulin-like growth factor-I (IGF-IEa) and its splice variant, mechano-growth factor (MGF), isolated from active skeletal muscle. cDNAs of these peptides were injected into the facial muscle of adult rats prior to facial nerve avulsion. This resulted in significant neuroprotection of 88% and 37%, respectively, of motoneurons compared to control plasmid and avulsion-only groups. MGF is markedly more effective than the liver-type, systemic IGF-I for motoneuron survival, suggesting a major role for the peripheral target in adult neuronal maintenance and survival.

Original language	English
Pages (from-to)	213-218
Number of pages	6
Journal	Brain Research
Volume	1009
Issue number	1-2
DOIs	https://doi.org/10.1016/j.brainres.2004.02.049
Publication status	Published - 29 May 2004
Externally published	Yes

Keywords

Adult
Avulsion
Facial nerve
IGF-I
MGF
Motoneuron
Motor systems and sensorimotor integration
Spinal cord and brainstem

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10.1016/j.brainres.2004.02.049

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abstract = "We compared the neuroprotective effects of a liver-type isoform of insulin-like growth factor-I (IGF-IEa) and its splice variant, mechano-growth factor (MGF), isolated from active skeletal muscle. cDNAs of these peptides were injected into the facial muscle of adult rats prior to facial nerve avulsion. This resulted in significant neuroprotection of 88% and 37%, respectively, of motoneurons compared to control plasmid and avulsion-only groups. MGF is markedly more effective than the liver-type, systemic IGF-I for motoneuron survival, suggesting a major role for the peripheral target in adult neuronal maintenance and survival.",

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AU - Johnson, Ian P.

AU - Cannon, John

AU - Yang, Shi-Yu

AU - Goldspink, Geoffrey

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Different levels of neuroprotection by two insulin-like growth factor-I splice variants

Abstract

Keywords

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