Differential brain effects of laser and needle acupuncture at LR8 using functional MRI

Im Quah-Smith, Mark A. Williams, Thomas Lundeberg, Chao Suo, Perminder Sachdev*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    33 Citations (Scopus)
    51 Downloads (Pure)


    Objective While needle acupuncture is a well-accepted technique, laser acupuncture is being increasingly used in clinical practice. The differential effects of the two techniques are of interest. We examine this in relation to brain effects of activation of LR8, a putative acupuncture point for depression, using functional MRI (fMRI). Methods Sixteen healthy participants were randomised to receive low intensity laser acupuncture to LR8 on one side and needle acupuncture to the contralateral LR8. Stimulation was in an on-off block design and brain patterns were recorded under fMRI. Results Significant activation occurred in the left precuneus during laser acupuncture compared with needle acupuncture and significant activation occurred in the left precentral gyrus during needle acupuncture compared with laser acupuncture. Conclusions Laser and needle acupuncture at LR8 in healthy participants produced different brain patterns. Laser acupuncture activated the precuneus relevant to mood in the posterior default mode network while needle acupuncture activated the parietal cortical region associated with the primary motor cortex. Further investigations are warranted to evaluate the clinical relevance of these effects.

    Original languageEnglish
    Pages (from-to)282-289
    Number of pages8
    JournalAcupuncture in Medicine
    Issue number3
    Publication statusPublished - Sept 2013

    Bibliographical note

    This article has been accepted for publication in Acupuncture in Medicine following peer review and can also be viewed on the journal’s website at http://aim.bmj.com/. This article was published in Acupuncture in Medicine, Vol. 31, No. 3, pp. 282-289.


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