TY - JOUR
T1 - Disability and life satisfaction in neurological disorders
T2 - the role of depression and perceived cognitive difficulties
AU - Gandy, Milena
AU - Heriseanu, Andreea I.
AU - Dudeney, Joanne
AU - Bisby, Madelyne A.
AU - Scott, Amelia J.
AU - Fisher, Alana
AU - Hathway, Taylor
AU - Karin, Eyal
AU - Titov, Nick
AU - Dear, Blake F.
N1 - Copyright © 2021 Elsevier Inc. All rights reserved.
PY - 2021/11
Y1 - 2021/11
N2 - Background: This study assessed factors associated with disability and life satisfaction in a large cohort of 2246 Australian adults with neurological disorders who completed an online survey of mental health and wellbeing. It was hypothesised that depressive symptoms and perceived cognitive difficulties would be significantly associated with both outcomes, even after controlling for significant demographic/medical covariates (e.g., age, marital-status, employment, multi-morbidity, medication). Differences in profiles of four neurological subgroups (i.e., multiple sclerosis; n = 738, epilepsy; n = 672, Parkinson's disease; n = 263, and Acquired Bran Injury; n = 278) were explored.Methods: Multiple hierarchical linear regressions were run using cross-sectional data.Results: Depressive symptoms made a significant and large unique contribution to higher levels of disability (β = 0.333, p < .001), and poorer life satisfaction (β = -0.434, p < .001), in the overall sample and across all four neurological subgroups (β = 0.349 to 0.513, p < .001) Greater perceived cognitive difficulties were associated with disability in the overall sample (β = 0.318, p < .001) and across all neurological subgroups (β = 0.231 to 0.354, p < .001), but only life satisfaction in epilepsy (β = -0.107, p = 006).Conclusions: The findings underscore the importance of managing psychological/neuropsychiatric comorbidities in neurological disorders.
AB - Background: This study assessed factors associated with disability and life satisfaction in a large cohort of 2246 Australian adults with neurological disorders who completed an online survey of mental health and wellbeing. It was hypothesised that depressive symptoms and perceived cognitive difficulties would be significantly associated with both outcomes, even after controlling for significant demographic/medical covariates (e.g., age, marital-status, employment, multi-morbidity, medication). Differences in profiles of four neurological subgroups (i.e., multiple sclerosis; n = 738, epilepsy; n = 672, Parkinson's disease; n = 263, and Acquired Bran Injury; n = 278) were explored.Methods: Multiple hierarchical linear regressions were run using cross-sectional data.Results: Depressive symptoms made a significant and large unique contribution to higher levels of disability (β = 0.333, p < .001), and poorer life satisfaction (β = -0.434, p < .001), in the overall sample and across all four neurological subgroups (β = 0.349 to 0.513, p < .001) Greater perceived cognitive difficulties were associated with disability in the overall sample (β = 0.318, p < .001) and across all neurological subgroups (β = 0.231 to 0.354, p < .001), but only life satisfaction in epilepsy (β = -0.107, p = 006).Conclusions: The findings underscore the importance of managing psychological/neuropsychiatric comorbidities in neurological disorders.
KW - quality of life
KW - predictors
KW - neuropsychiatric
KW - neurology
KW - mental health
KW - subjective cognitive complaints
UR - http://www.scopus.com/inward/record.url?scp=85114503679&partnerID=8YFLogxK
U2 - 10.1016/j.genhosppsych.2021.08.013
DO - 10.1016/j.genhosppsych.2021.08.013
M3 - Article
C2 - 34508992
SN - 0163-8343
VL - 73
SP - 16
EP - 23
JO - General Hospital Psychiatry
JF - General Hospital Psychiatry
ER -