Discovery and heterologous biosynthesis of the burnettramic acids: rare PKS-NRPS-derived bolaamphiphilic pyrrolizidinediones from an Australian fungus, Aspergillus burnettii

Hang Li, Cameron L. M. Gilchrist, Heather J. Lacey, Andrew Crombie, Daniel Vuong, John I. Pitt, Ernest Lacey, Yit-Heng Chooi, Andrew M. Piggott

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)
3 Downloads (Pure)

Abstract

The burnettramic acids are a new class of antibiotics from an Australian fungus Aspergillus burnettii. The rare bolaamphiphilic scaffold consists of β-d-mannose linked to a pyrrolizidinedione unit via a 26-carbon chain. The most abundant metabolite displayed potent in vitro antifungal activity. Comparative genomics identified the hybrid PKS-NRPS bua gene cluster, which was verified by heterologous pathway reconstitution in Aspergillus nidulans.

Original languageEnglish
Pages (from-to)1287-1291
Number of pages5
JournalOrganic Letters
Volume21
Issue number5
DOIs
Publication statusPublished - 1 Mar 2019

Bibliographical note

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