Discovery of a novel biomarker in the urine in women with endometriosis

Natsuko Tokushige; Robert Markham; Ben Crossett; Seong B. Ahn; Vidya L. Nelaturi; Alamgir Khan; Ian S. Fraser

doi:10.1016/j.fertnstert.2010.05.016

Discovery of a novel biomarker in the urine in women with endometriosis

Natsuko Tokushige^*, Robert Markham, Ben Crossett, Seong B. Ahn, Vidya L. Nelaturi, Alamgir Khan, Ian S. Fraser

^*Corresponding author for this work

Department of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Objective: To investigate whether proteins secreted in urine differ between women with and without endometriosis. Design: Laboratory study using human urine. Setting: University-based laboratory. Patient(s): Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. Intervention(s): Urine collection from women with and without endometriosis. Main Outcome Measure(s): Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis. Result(s): On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis. Conclusion(s): Cytokeratin-19 may be a valuable urinary biomarker for endometriosis.

Original language	English
Pages (from-to)	46-49
Number of pages	4
Journal	Fertility and Sterility
Volume	95
Issue number	1
DOIs	https://doi.org/10.1016/j.fertnstert.2010.05.016
Publication status	Published - Jan 2011

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title = "Discovery of a novel biomarker in the urine in women with endometriosis",

abstract = "Objective: To investigate whether proteins secreted in urine differ between women with and without endometriosis. Design: Laboratory study using human urine. Setting: University-based laboratory. Patient(s): Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. Intervention(s): Urine collection from women with and without endometriosis. Main Outcome Measure(s): Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis. Result(s): On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis. Conclusion(s): Cytokeratin-19 may be a valuable urinary biomarker for endometriosis.",

author = "Natsuko Tokushige and Robert Markham and Ben Crossett and Ahn, {Seong B.} and Nelaturi, {Vidya L.} and Alamgir Khan and Fraser, {Ian S.}",

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AU - Tokushige, Natsuko

AU - Markham, Robert

AU - Crossett, Ben

AU - Ahn, Seong B.

AU - Nelaturi, Vidya L.

AU - Khan, Alamgir

AU - Fraser, Ian S.

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N2 - Objective: To investigate whether proteins secreted in urine differ between women with and without endometriosis. Design: Laboratory study using human urine. Setting: University-based laboratory. Patient(s): Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. Intervention(s): Urine collection from women with and without endometriosis. Main Outcome Measure(s): Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis. Result(s): On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis. Conclusion(s): Cytokeratin-19 may be a valuable urinary biomarker for endometriosis.

AB - Objective: To investigate whether proteins secreted in urine differ between women with and without endometriosis. Design: Laboratory study using human urine. Setting: University-based laboratory. Patient(s): Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. Intervention(s): Urine collection from women with and without endometriosis. Main Outcome Measure(s): Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis. Result(s): On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis. Conclusion(s): Cytokeratin-19 may be a valuable urinary biomarker for endometriosis.

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