Discovery of a novel biomarker in the urine in women with endometriosis

Natsuko Tokushige*, Robert Markham, Ben Crossett, Seong B. Ahn, Vidya L. Nelaturi, Alamgir Khan, Ian S. Fraser

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    32 Citations (Scopus)

    Abstract

    Objective: To investigate whether proteins secreted in urine differ between women with and without endometriosis. Design: Laboratory study using human urine. Setting: University-based laboratory. Patient(s): Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. Intervention(s): Urine collection from women with and without endometriosis. Main Outcome Measure(s): Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis. Result(s): On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis. Conclusion(s): Cytokeratin-19 may be a valuable urinary biomarker for endometriosis.

    Original languageEnglish
    Pages (from-to)46-49
    Number of pages4
    JournalFertility and Sterility
    Volume95
    Issue number1
    DOIs
    Publication statusPublished - Jan 2011

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