Discovery of a novel biomarker in the urine in women with endometriosis

Natsuko Tokushige; Robert Markham; Ben Crossett; Seong B. Ahn; Vidya L. Nelaturi; Alamgir Khan; Ian S. Fraser

doi:10.1016/j.fertnstert.2010.05.016

Discovery of a novel biomarker in the urine in women with endometriosis

Natsuko Tokushige^*, Robert Markham, Ben Crossett, Seong B. Ahn, Vidya L. Nelaturi, Alamgir Khan, Ian S. Fraser

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Objective: To investigate whether proteins secreted in urine differ between women with and without endometriosis. Design: Laboratory study using human urine. Setting: University-based laboratory. Patient(s): Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. Intervention(s): Urine collection from women with and without endometriosis. Main Outcome Measure(s): Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis. Result(s): On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis. Conclusion(s): Cytokeratin-19 may be a valuable urinary biomarker for endometriosis.

Original language	English
Pages (from-to)	46-49
Number of pages	4
Journal	Fertility and Sterility
Volume	95
Issue number	1
DOIs	https://doi.org/10.1016/j.fertnstert.2010.05.016
Publication status	Published - Jan 2011

Access to Document

10.1016/j.fertnstert.2010.05.016

Cite this

@article{fd12b2fee57e4ab5b89bb92c82e71523,

title = "Discovery of a novel biomarker in the urine in women with endometriosis",

abstract = "Objective: To investigate whether proteins secreted in urine differ between women with and without endometriosis. Design: Laboratory study using human urine. Setting: University-based laboratory. Patient(s): Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. Intervention(s): Urine collection from women with and without endometriosis. Main Outcome Measure(s): Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis. Result(s): On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis. Conclusion(s): Cytokeratin-19 may be a valuable urinary biomarker for endometriosis.",

author = "Natsuko Tokushige and Robert Markham and Ben Crossett and Ahn, {Seong B.} and Nelaturi, {Vidya L.} and Alamgir Khan and Fraser, {Ian S.}",

year = "2011",

month = jan,

doi = "10.1016/j.fertnstert.2010.05.016",

language = "English",

volume = "95",

pages = "46--49",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Discovery of a novel biomarker in the urine in women with endometriosis

AU - Tokushige, Natsuko

AU - Markham, Robert

AU - Crossett, Ben

AU - Ahn, Seong B.

AU - Nelaturi, Vidya L.

AU - Khan, Alamgir

AU - Fraser, Ian S.

PY - 2011/1

Y1 - 2011/1

N2 - Objective: To investigate whether proteins secreted in urine differ between women with and without endometriosis. Design: Laboratory study using human urine. Setting: University-based laboratory. Patient(s): Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. Intervention(s): Urine collection from women with and without endometriosis. Main Outcome Measure(s): Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis. Result(s): On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis. Conclusion(s): Cytokeratin-19 may be a valuable urinary biomarker for endometriosis.

AB - Objective: To investigate whether proteins secreted in urine differ between women with and without endometriosis. Design: Laboratory study using human urine. Setting: University-based laboratory. Patient(s): Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. Intervention(s): Urine collection from women with and without endometriosis. Main Outcome Measure(s): Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis. Result(s): On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis. Conclusion(s): Cytokeratin-19 may be a valuable urinary biomarker for endometriosis.

UR - http://www.scopus.com/inward/record.url?scp=78650415288&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2010.05.016

DO - 10.1016/j.fertnstert.2010.05.016

M3 - Article

C2 - 21168580

AN - SCOPUS:78650415288

SN - 0015-0282

VL - 95

SP - 46

EP - 49

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 1

ER -

Discovery of a novel biomarker in the urine in women with endometriosis

Abstract

Access to Document

Other files and links

Fingerprint

Cite this