Projects per year
Abstract
The brevijanazines are novel p-nitrobenzoylated piperazines isolated from Aspergillus brevijanus. Their structures were elucidated by spectroscopic analysis, X-ray crystallography and total synthesis. Heterologous biosynthesis, precursor feeding and in vitro microsomal assays unveiled the biosynthetic pathway to the brevijanazines, featuring a cytochrome P450 oxygenase that converts p-aminobenzoic acid to p-nitrobenzoic acid.
Original language | English |
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Pages (from-to) | 6296-6299 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 58 |
Issue number | 43 |
Early online date | 4 May 2022 |
DOIs | |
Publication status | Published - 28 May 2022 |
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Dive into the research topics of 'Discovery of brevijanazines from Aspergillus brevijanus reveals the molecular basis for p-nitrobenzoic acid in fungi'. Together they form a unique fingerprint.Projects
- 2 Finished
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UWA led: CRISPR-based pathway activation for bioactive molecule discovery in fungi
Chooi, Y. H., Piggott, A. & Keller, N.
11/02/21 → 10/02/24
Project: Research
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BioAustralis, towards the future
Lacey, E., Piggott, A., Chooi, Y. H. & Page, S.
19/10/18 → 31/12/21
Project: Other