Disentangling interoception: Insights from focal strokes affecting the perception of external and internal milieus

Blas Couto, Federico Adolfi, Lucas Sedeño, Alejo Salles, Andrés Canales-Johnson, Pablo Alvarez-Abut, Indira Garcia-Cordero, Marcos Pietto, Tristan Bekinschtein, Mariano Sigman, Facundo Manes, Agustin Ibanez*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Interoception is the moment-to-moment sensing of the physiological condition of the body. The multimodal sources of interoception can be classified into two different streams of afferents: an internal pathway of signals arising from core structures (i.e., heart, blood vessels, and bronchi) and an external pathway of body-mapped sensations (i.e., chemosensation and pain) arising from peripersonal space. This study examines differential processing along these streams within the insular cortex (IC) and their subcortical tracts connecting frontotemporal networks. Two rare patients presenting focal lesions of the IC (insular lesion, IL) or its subcortical tracts (subcortical lesion, SL) were tested. Internally generated interoceptive streams were assessed through a heartbeat detection (HBD) task, while those externally triggered were tapped via taste, smell, and pain recognition tasks. A differential pattern was observed. The IC patient showed impaired internal signal processing while the SL patient exhibited external perception deficits. Such selective deficits remained even when comparing each patient with a group of healthy controls and a group of brain-damaged patients. These outcomes suggest the existence of distinguishable interoceptive streams. Results are discussed in relation with neuroanatomical substrates, involving a fronto-insulo-temporal network for interoceptive and cognitive contextual integration.

Original languageEnglish
Article number503
Pages (from-to)1-17
Number of pages17
JournalFrontiers in Psychology
Volume6
Issue numberMAY
DOIs
Publication statusPublished - 1 May 2015
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Exteroception
  • Interoception
  • Interoceptive awareness
  • Interoceptive sensitivity
  • Lesion
  • Peripersonal space
  • Stroke

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