Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia

Magdalena Przybyla, Claire H. Stevens, Julia van der Hoven, Anne Harasta, Mian Bi, Arne Ittner, Annika van Hummel, John R. Hodges, Olivier Piguet, Tim Karl, Michael Kassiou, Gary D. Housley, Yazi D. Ke, Lars M. Ittner*, Janet van Eersel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Frontotemporal dementia (FTD) presents clinically with behavioral changes including disinhibition. Mutations in the tau-encoding MAPT gene identified in familial cases of FTD have been used to generate transgenic mouse models of the human condition. Here, we report behavioral changes in a recently developed P301S mutant tau transgenic mouse, including disinhibition-like behavior in the elevated plus maze and hyperactivity in the open field arena. Furthermore, histological analysis revealed the amygdala as a primary and early site of pathological tau deposition in these mice. Taken together, neuropathological and behavioral changes in P301S tau transgenic mice resemble features of human FTD.

Original languageEnglish
Pages (from-to)24-29
Number of pages6
JournalNeuroscience Letters
Volume631
DOIs
Publication statusPublished - 19 Sep 2016
Externally publishedYes

Keywords

  • Behavior
  • Frontotemporal dementia
  • Tau
  • Transgenic mouse model

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