Disorder-specific versus transdiagnostic and clinician-guided versus self-guided treatment for major depressive disorder and comorbid anxiety disorders

a randomized controlled trial

N. Titov, B. F. Dear*, L. G. Staples, M. D. Terides, E. Karin, J. Sheehan, L. Johnston, M. Gandy, V. J. Fogliati, B. M. Wootton, P. M. McEvoy

*Corresponding author for this work

    Research output: Contribution to journalArticle

    92 Citations (Scopus)
    16 Downloads (Pure)

    Abstract

    Disorder-specific cognitive behavior therapy (DS-CBT) is effective at treating major depressive disorder (MDD) while transdiagnostic CBT (TD-CBT) addresses both principal and comorbid disorders by targeting underlying and common symptoms. The relative benefits of these two models of therapy have not been determined. Participants with MDD ( n= 290) were randomly allocated to receive an internet delivered TD-CBT or DS-CBT intervention delivered in either clinician-guided (CG-CBT) or self-guided (SG-CBT) formats. Large reductions in symptoms of MDD (Cohen's d≥. 1.44; avg. reduction. ≥ 45%) and moderate-to-large reductions in symptoms of comorbid generalised anxiety disorder (Cohen's d≥ 1.08; avg. reduction. ≥ 43%), social anxiety disorder (Cohen's d≥ 0.65; avg. reduction. ≥ 29%) and panic disorder (Cohen's d≥ 0.45; avg. reduction. ≥ 31%) were found. No marked or consistent differences were observed across the four conditions, highlighting the efficacy of different forms of CBT at treating MDD and comorbid disorders.

    Original languageEnglish
    Pages (from-to)88-102
    Number of pages15
    JournalJournal of Anxiety Disorders
    Volume35
    DOIs
    Publication statusPublished - 1 Oct 2015

    Bibliographical note

    Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

    Keywords

    • 24-month follow-up
    • Anxiety disorders
    • Disorder-specific
    • Internet
    • Major depressive disorder
    • Randomized controlled trial
    • Self- guided
    • Therapist-guided
    • Transdiagnostic
    • Treatment

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