Dissolving the missing heritability problem

Pierrick Bourrat, Qiaoying Lu

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Heritability estimates obtained from genome-wide association studies (GWAS) are much lower than those of traditional quantitative methods. This phenomenon has been called the “missing heritability problem." By analyzing and comparing GWAS and traditional quantitative methods, we first show that the estimates obtained from the latter involve some terms other than additive genetic variance, while the estimates fromthe former do not. Second, GWAS,when used to estimate heritability, do not take into account additive epigenetic factors transmitted across generations, while traditional quantitative methods do. Given these two points we show that the missing heritability problem can largely be dissolved.

LanguageEnglish
Pages1055-1067
Number of pages13
JournalPhilosophy of Science
Volume84
Issue number5
DOIs
Publication statusPublished - Dec 2017

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Heritability
Quantitative Methods
Genome
Epigenetics

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Bourrat, Pierrick ; Lu, Qiaoying. / Dissolving the missing heritability problem. In: Philosophy of Science. 2017 ; Vol. 84, No. 5. pp. 1055-1067.
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Dissolving the missing heritability problem. / Bourrat, Pierrick; Lu, Qiaoying.

In: Philosophy of Science, Vol. 84, No. 5, 12.2017, p. 1055-1067.

Research output: Contribution to journalArticleResearchpeer-review

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