Distinctive autofluorescence of urine samples from individuals with bacteriuria compared with normals

Ayad G. Anwer, Perinchery M. Sandeep, Ewa M. Goldys, Subramanyam Vemulpad*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)

    Abstract

    Background: A variety of fluorophores are present in normal human urine. Alteration in the autofluorescence of urine could result from physiological or pathological changes. Method: This study investigates the differences in the autofluorescence of 45 normal urine samples from 25 individuals with bacteriuria. Results: Excitation at 290 nm showed good discrimination between these 2 groups. Principal Component Analysis (PCA) of the data revealed statistically significant differences between the fluorescence spectra for samples with bacteriuria as compared to the control group. Conclusion: The findings indicate the potential of the fluorescence spectrum of urine to be developed as a simple and rapid diagnostic tool.

    Original languageEnglish
    Pages (from-to)73-75
    Number of pages3
    JournalClinica Chimica Acta
    Volume401
    Issue number1-2
    DOIs
    Publication statusPublished - Mar 2009

    Keywords

    • autofluorescence
    • human urine
    • bacteriuria
    • urinary tract infection
    • diagnostic tests
    • IDO

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