TY - JOUR
T1 - Distinguishing Subtypes in Primary Progressive Aphasia
T2 - Application of the Sydney Language Battery
AU - Savage, Sharon
AU - Hsieh, Sharpley
AU - Leslie, Felicity
AU - Foxe, David
AU - Piguet, Olivier
AU - Hodges, John R.
PY - 2013
Y1 - 2013
N2 - Background/Aims: Primary progressive aphasia (PPA) comprises three main subtypes, varying in clinical features, patterns of brain atrophy, and underlying pathology. Differentiation of these variants is important for treatment and planning; however, simple, effective cognitive tests to aid diagnosis are lacking. This study introduces a new language battery - the SYDBAT (Sydney Language Battery) - to assist clinicians. Methods: Fifty-seven PPA patients and 54 age- and education-matched healthy controls were compared on naming, repetition, word comprehension, and semantic association subtests. Results: Significant group differences were found for all tasks, reflecting different language profiles for each group. Using discriminative function analysis, 80% of PPA cases were correctly classified from three SYDBAT scores, from which a simple diagnostic algorithm was defined. Conclusion: The SYDBAT is a fast and simple tool which provides a valuable adjunct to clinicians diagnosing PPA.
AB - Background/Aims: Primary progressive aphasia (PPA) comprises three main subtypes, varying in clinical features, patterns of brain atrophy, and underlying pathology. Differentiation of these variants is important for treatment and planning; however, simple, effective cognitive tests to aid diagnosis are lacking. This study introduces a new language battery - the SYDBAT (Sydney Language Battery) - to assist clinicians. Methods: Fifty-seven PPA patients and 54 age- and education-matched healthy controls were compared on naming, repetition, word comprehension, and semantic association subtests. Results: Significant group differences were found for all tasks, reflecting different language profiles for each group. Using discriminative function analysis, 80% of PPA cases were correctly classified from three SYDBAT scores, from which a simple diagnostic algorithm was defined. Conclusion: The SYDBAT is a fast and simple tool which provides a valuable adjunct to clinicians diagnosing PPA.
KW - Clinical diagnosis
KW - Cognitive assessment
KW - Naming
KW - Primary progressive aphasia
KW - Semantic knowledge
KW - Word repetition
UR - http://www.scopus.com/inward/record.url?scp=84874615546&partnerID=8YFLogxK
U2 - 10.1159/000346389
DO - 10.1159/000346389
M3 - Article
C2 - 23467307
AN - SCOPUS:84874615546
SN - 1420-8008
VL - 35
SP - 208
EP - 218
JO - Dementia and Geriatric Cognitive Disorders
JF - Dementia and Geriatric Cognitive Disorders
IS - 3-4
ER -