Divergent influenza-like viruses of amphibians and fish support an ancient evolutionary association

Rhys Parry*, Michelle Wille*, Olivia M. H. Turnbull, Jemma L. Geoghegan, Edward C. Holmes*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Influenza viruses (family Orthomyxoviridae) infect a variety of vertebrates, including birds, humans, and other mammals. Recent metatranscriptomic studies have uncovered divergent influenza viruses in amphibians, fish and jawless vertebrates, suggesting that these viruses may be widely distributed. We sought to identify additional vertebrate influenza-like viruses through the analysis of publicly available RNA sequencing data. Accordingly, by data mining, we identified the complete coding segments of five divergent vertebrate influenza-like viruses. Three fell as sister lineages to influenza B virus: salamander influenza-like virus in Mexican walking fish (Ambystoma mexicanum) and plateau tiger salamander (Ambystoma velasci), Siamese algae-eater influenza-like virus in Siamese algae-eater fish (Gyrinocheilus aymonieri) and chum salmon influenza-like virus in chum salmon (Oncorhynchus keta). Similarly, we identified two influenza-like viruses of amphibians that fell as sister lineages to influenza D virus: cane toad influenza-like virus and the ornate chorus frog influenza-like virus, in the cane toad (Rhinella marina) and ornate chorus frog (Microhyla fissipes), respectively. Despite their divergent phylogenetic positions, these viruses retained segment conservation and splicing consistent with transcriptional regulation in influenza B and influenza D viruses, and were detected in respiratory tissues. These data suggest that influenza viruses have been associated with vertebrates for their entire evolutionary history.

Original languageEnglish
Article number1042
Pages (from-to)1-14
Number of pages14
JournalViruses
Volume12
Issue number9
DOIs
Publication statusPublished - Sep 2020

Bibliographical note

Funding Information:
R.P. is supported by a University of Queensland scholarship. E.C.H. is funded by an Australian Research Council Australian Laureate Fellowship (FL170100022). M.W. is supported by an Australian Research Council Discovery Early Career Researcher Award (DE200100977). J.L.G. and E.C.H. are also funded by an Australian Research Council Discovery Project (DP200102351).

Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Amphibians
  • Evolution
  • Fish
  • Influenza
  • Metatranscriptomics
  • Orthomyxoviridae
  • Phylogeny

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