Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement

Alpesh R. Patel, Ari Hardianto, Shoba Ranganathan, Fei Liu

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Acquiring a divergent response from homologous protein domains is essential for selective ligand-protein interactions. Stereospecific fluorination of (−)-balanol, an ATP mimic, uncovers a new source of selectivity from integrated chemical and conformational perturbation that differentiates homologous sites by the level of congruency in their response to local and remote fluorine effects.

LanguageEnglish
Pages1570-1574
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume15
Issue number7
DOIs
Publication statusPublished - 21 Feb 2017

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Fluorination
fluorination
Fluorine
adenosine triphosphate
Halogenation
Adenosine Triphosphate
selectivity
Ligands
proteins
ligands
augmentation
fluorine
Proteins
perturbation
interactions
ophiocordin
Protein Domains

Cite this

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Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement. / Patel, Alpesh R.; Hardianto, Ari; Ranganathan, Shoba; Liu, Fei.

In: Organic and Biomolecular Chemistry, Vol. 15, No. 7, 21.02.2017, p. 1570-1574.

Research output: Contribution to journalArticleResearchpeer-review

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