Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement

Alpesh R. Patel, Ari Hardianto, Shoba Ranganathan, Fei Liu*

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Acquiring a divergent response from homologous protein domains is essential for selective ligand-protein interactions. Stereospecific fluorination of (−)-balanol, an ATP mimic, uncovers a new source of selectivity from integrated chemical and conformational perturbation that differentiates homologous sites by the level of congruency in their response to local and remote fluorine effects.

Original languageEnglish
Pages (from-to)1570-1574
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume15
Issue number7
DOIs
Publication statusPublished - 21 Feb 2017

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