Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement

Alpesh R. Patel; Ari Hardianto; Shoba Ranganathan; Fei Liu

doi:10.1039/c7ob00129k

Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement

Alpesh R. Patel
, Ari Hardianto
, Shoba Ranganathan
, Fei Liu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Acquiring a divergent response from homologous protein domains is essential for selective ligand-protein interactions. Stereospecific fluorination of (−)-balanol, an ATP mimic, uncovers a new source of selectivity from integrated chemical and conformational perturbation that differentiates homologous sites by the level of congruency in their response to local and remote fluorine effects.

Original language	English
Pages (from-to)	1570-1574
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	15
Issue number	7
DOIs	https://doi.org/10.1039/c7ob00129k
Publication status	Published - 21 Feb 2017

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title = "Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement",

abstract = "Acquiring a divergent response from homologous protein domains is essential for selective ligand-protein interactions. Stereospecific fluorination of (−)-balanol, an ATP mimic, uncovers a new source of selectivity from integrated chemical and conformational perturbation that differentiates homologous sites by the level of congruency in their response to local and remote fluorine effects.",

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T1 - Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement

AU - Patel, Alpesh R.

AU - Hardianto, Ari

AU - Ranganathan, Shoba

AU - Liu, Fei

PY - 2017/2/21

Y1 - 2017/2/21

N2 - Acquiring a divergent response from homologous protein domains is essential for selective ligand-protein interactions. Stereospecific fluorination of (−)-balanol, an ATP mimic, uncovers a new source of selectivity from integrated chemical and conformational perturbation that differentiates homologous sites by the level of congruency in their response to local and remote fluorine effects.

AB - Acquiring a divergent response from homologous protein domains is essential for selective ligand-protein interactions. Stereospecific fluorination of (−)-balanol, an ATP mimic, uncovers a new source of selectivity from integrated chemical and conformational perturbation that differentiates homologous sites by the level of congruency in their response to local and remote fluorine effects.

UR - https://www.scopus.com/pages/publications/85013055115

U2 - 10.1039/c7ob00129k

DO - 10.1039/c7ob00129k

M3 - Article

C2 - 28119986

AN - SCOPUS:85013055115

SN - 1477-0520

VL - 15

SP - 1570

EP - 1574

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 7

ER -

Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement

Abstract

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