DNA as a catalyst and catalytic template for the racemisation of metal tris-phenanthroline complexes

Alison Rodger*, Bengt Nordén, P. Mark Rodger, Paula J. Bates

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

[Fe(1,10-phenanthroline)3]2+ is known to racemise in solution and DNA is known to shift the equilibrium point of the Δ/Λ[Fe(1,10-phenanthroline)3]2+ mixture from 50:50 to a position favouring a slight excess of the Δ enantiomer. In this paper it is shown that DNA catalyses the racemisation reaction, presumably by providing vibrational energy to species that bind in a less favoured mode for that enantiomer. The racemisation of [Co(1,10-phenanthroline)3]3+, however, is not enhanced by DNA unless [Co(1,10-phenanthroline)3]2+ is also added to the solution. In this case, the DNA acts as a template to facilitate the CoII ⇄ CoIII electron transfer. Racemisation occurs while the [Co(1,10-phenanthroline)3]n+ is in the labile CoII form.

Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalEuropean Journal of Inorganic Chemistry
Issue number1
Publication statusPublished - 2002
Externally publishedYes

Keywords

  • Bioinorganic chemistry
  • Circular dichroism
  • Coordination chemistry
  • Racemisation

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