DNA focusing in nanofluidic channels

W. L. Hsu*, M. A. Startsev, D. W. Inglis, E. M. Goldys, M. R. Davidson, D. J E Harvie

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

Abstract

We use Computational Fluid Dynamics simulations to examine how dsDNA molecules are trapped in a concentration gradient-based electroosmotic-flow contained within a silica nanochannel. The simulations reveal that the electroosmotic velocity within the channel reverses near the trap location, increasing the efficiency of the trap, but also hindering its ability to discriminate between different dsDNA lengths. Qualitatively, the behaviour is observed experimentally.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Place of PublicationRed Hook, NY
PublisherChemical and Biological Microsystems Society
Pages766-768
Number of pages3
Volume2
ISBN (Print)9781632666246
Publication statusPublished - 2013
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: 27 Oct 201331 Oct 2013

Other

Other17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
CountryGermany
CityFreiburg
Period27/10/1331/10/13

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