DNA focusing in nanofluidic channels

W. L. Hsu; M. A. Startsev; D. W. Inglis; E. M. Goldys; M. R. Davidson; D. J E Harvie

DNA focusing in nanofluidic channels

W. L. Hsu^*, M. A. Startsev, D. W. Inglis, E. M. Goldys, M. R. Davidson, D. J E Harvie

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

Abstract

We use Computational Fluid Dynamics simulations to examine how dsDNA molecules are trapped in a concentration gradient-based electroosmotic-flow contained within a silica nanochannel. The simulations reveal that the electroosmotic velocity within the channel reverses near the trap location, increasing the efficiency of the trap, but also hindering its ability to discriminate between different dsDNA lengths. Qualitatively, the behaviour is observed experimentally.

Original language	English
Title of host publication	17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Place of Publication	Red Hook, NY
Publisher	Chemical and Biological Microsystems Society
Pages	766-768
Number of pages	3
Volume	2
ISBN (Print)	9781632666246
Publication status	Published - 2013
Event	17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany Duration: 27 Oct 2013 → 31 Oct 2013

Other

Other	17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Country/Territory	Germany
City	Freiburg
Period	27/10/13 → 31/10/13

Cite this

@inproceedings{76239fbc1ad34405bfd604edf038cd1f,

title = "DNA focusing in nanofluidic channels",

abstract = "We use Computational Fluid Dynamics simulations to examine how dsDNA molecules are trapped in a concentration gradient-based electroosmotic-flow contained within a silica nanochannel. The simulations reveal that the electroosmotic velocity within the channel reverses near the trap location, increasing the efficiency of the trap, but also hindering its ability to discriminate between different dsDNA lengths. Qualitatively, the behaviour is observed experimentally.",

author = "Hsu, {W. L.} and Startsev, {M. A.} and Inglis, {D. W.} and Goldys, {E. M.} and Davidson, {M. R.} and Harvie, {D. J E}",

year = "2013",

language = "English",

isbn = "9781632666246",

volume = "2",

pages = "766--768",

booktitle = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013",

publisher = "Chemical and Biological Microsystems Society",

note = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 ; Conference date: 27-10-2013 Through 31-10-2013",

}

Hsu, WL, Startsev, MA, Inglis, DW, Goldys, EM, Davidson, MR & Harvie, DJE 2013, DNA focusing in nanofluidic channels. in 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. vol. 2, Chemical and Biological Microsystems Society, Red Hook, NY, pp. 766-768, 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, Freiburg, Germany, 27/10/13.

DNA focusing in nanofluidic channels. / Hsu, W. L.; Startsev, M. A.; Inglis, D. W. et al.
17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Vol. 2 Red Hook, NY: Chemical and Biological Microsystems Society, 2013. p. 766-768.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

TY - GEN

T1 - DNA focusing in nanofluidic channels

AU - Hsu, W. L.

AU - Startsev, M. A.

AU - Inglis, D. W.

AU - Goldys, E. M.

AU - Davidson, M. R.

AU - Harvie, D. J E

PY - 2013

Y1 - 2013

N2 - We use Computational Fluid Dynamics simulations to examine how dsDNA molecules are trapped in a concentration gradient-based electroosmotic-flow contained within a silica nanochannel. The simulations reveal that the electroosmotic velocity within the channel reverses near the trap location, increasing the efficiency of the trap, but also hindering its ability to discriminate between different dsDNA lengths. Qualitatively, the behaviour is observed experimentally.

AB - We use Computational Fluid Dynamics simulations to examine how dsDNA molecules are trapped in a concentration gradient-based electroosmotic-flow contained within a silica nanochannel. The simulations reveal that the electroosmotic velocity within the channel reverses near the trap location, increasing the efficiency of the trap, but also hindering its ability to discriminate between different dsDNA lengths. Qualitatively, the behaviour is observed experimentally.

UR - http://www.scopus.com/inward/record.url?scp=84907334564&partnerID=8YFLogxK

M3 - Conference proceeding contribution

AN - SCOPUS:84907334564

SN - 9781632666246

VL - 2

SP - 766

EP - 768

BT - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013

PB - Chemical and Biological Microsystems Society

CY - Red Hook, NY

T2 - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013

Y2 - 27 October 2013 through 31 October 2013

ER -

DNA focusing in nanofluidic channels

Abstract

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