DNA nanoclew templated spherical nucleic acids for siRNA delivery

Weimin Ruan, Meng Zheng, Yang An, Yuanyuan Liu, David Lovejoy, Mingcong Hao, Yan Zou, Albert Lee, Shu Yang, Yiqing Lu, Marco Morsch, Roger Chung, Bingyang Shi

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


A superior biocompatible spherical nucleic acid (SNA) conjugate was fabricated by grafting siRNA onto the surface of a core composed of a spherical DNA nanostucture we have termed a DNA nanoclew (DC). After uptake by cultured cancer cells, these SNA nanoparticles release engrafted siRNAs by cleavage of intracellular Dicer enzyme. Moreover, in vitro expriments display that such SNAs demonstrate potent gene knockdown at both miRNA and protein levels, while with negligible cytotoxicity.
Original languageEnglish
Pages (from-to)3609-3612
Number of pages4
JournalChemical Communications
Publication statusPublished - 14 Apr 2018


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