Does autoimmunity against thyroglobulin play a role in the pathogenesis of Graves' ophthalmopathy: a review

Thayalini Shanmuganathan; Christian Girgis; Hooshang Lahooti; Bernard Champion; Jack R. Wall

doi:10.2147/OPTH.S88444

Does autoimmunity against thyroglobulin play a role in the pathogenesis of Graves' ophthalmopathy: a review

Thayalini Shanmuganathan, Christian Girgis, Hooshang Lahooti, Bernard Champion, Jack R. Wall

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Abstract

While most authors believe that autoimmunity against the TSH receptor expressed in the orbital connective tissue cells is the main reaction that leads to the development of ophthalmopathy in patients with Graves' hyperthyroidism, an older hypothesis that deserves fresh consideration is based on the notion that thyroglobulin (Tg) in the thyroid gland passes in a retrograde fashion to the orbit where it is recognized by Tg autoantibodies, leading to inflammation. Here, we review new evidence that supports a role of Tg and propose a new hypothesis based on the notion that Tg is targeted in the orbit leading to a complex cascade of reactions that leads to Graves' ophthalmopathy.

Original language	English
Pages (from-to)	2271-2276
Number of pages	6
Journal	Clinical Ophthalmology
Volume	9
DOIs	https://doi.org/10.2147/OPTH.S88444
Publication status	Published - 2015
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Graves' disease
TSH receptor
autoantibodies
lymphocytes
ophthalmopathy
thyroglobulin
thyroid peroxidase

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10.2147/OPTH.S88444

Mq-60371-Publisher version (open access)Final published version, 418 KBLicence: Unspecified

Cite this

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abstract = "While most authors believe that autoimmunity against the TSH receptor expressed in the orbital connective tissue cells is the main reaction that leads to the development of ophthalmopathy in patients with Graves' hyperthyroidism, an older hypothesis that deserves fresh consideration is based on the notion that thyroglobulin (Tg) in the thyroid gland passes in a retrograde fashion to the orbit where it is recognized by Tg autoantibodies, leading to inflammation. Here, we review new evidence that supports a role of Tg and propose a new hypothesis based on the notion that Tg is targeted in the orbit leading to a complex cascade of reactions that leads to Graves' ophthalmopathy.",

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AU - Lahooti, Hooshang

AU - Champion, Bernard

AU - Wall, Jack R.

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Does autoimmunity against thyroglobulin play a role in the pathogenesis of Graves' ophthalmopathy: a review

Abstract

Bibliographical note

Keywords

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