Does autoimmunity against thyroglobulin play a role in the pathogenesis of Graves' ophthalmopathy

a review

Thayalini Shanmuganathan, Christian Girgis, Hooshang Lahooti, Bernard Champion, Jack R. Wall

Research output: Contribution to journalArticle

6 Citations (Scopus)
16 Downloads (Pure)


While most authors believe that autoimmunity against the TSH receptor expressed in the orbital connective tissue cells is the main reaction that leads to the development of ophthalmopathy in patients with Graves' hyperthyroidism, an older hypothesis that deserves fresh consideration is based on the notion that thyroglobulin (Tg) in the thyroid gland passes in a retrograde fashion to the orbit where it is recognized by Tg autoantibodies, leading to inflammation. Here, we review new evidence that supports a role of Tg and propose a new hypothesis based on the notion that Tg is targeted in the orbit leading to a complex cascade of reactions that leads to Graves' ophthalmopathy.
Original languageEnglish
Pages (from-to)2271-2276
Number of pages6
JournalClinical Ophthalmology
Publication statusPublished - 2015
Externally publishedYes


Bibliographical note

Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • Graves' disease
  • TSH receptor
  • autoantibodies
  • lymphocytes
  • ophthalmopathy
  • thyroglobulin
  • thyroid peroxidase

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