Does colchicine work? The results of the first controlled study in acute gout

M. J. Ahern, C. Reid, T. P. Gordon, Margaret McCredie, P M Brooks, M. Jones

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Abstract

We have performed the first controlled study of colchicine in acute gout, to determine its efficacy and toxicity, and to define the natural history of acute gout. Two-thirds of colchicine-treated patients improved afer 48 hours, but only one-third of the patients receiving placebo demonstrated similar improvement. The colchicine-treated patients responded earlier; significant differences from placebo were shown after 18-30 hours. All patients given colchicine developed diarrhea after a median time of 24 hours (mean dose of colchicine 6.7 mg). This side effect occurred before relief of pain in most patients.

Original languageEnglish
Pages (from-to)301-304
Number of pages4
JournalAustralian and New Zealand Journal of Medicine
Volume17
Issue number3
Publication statusPublished - 1987
Externally publishedYes

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    Ahern, M. J., Reid, C., Gordon, T. P., McCredie, M., Brooks, P. M., & Jones, M. (1987). Does colchicine work? The results of the first controlled study in acute gout. Australian and New Zealand Journal of Medicine, 17(3), 301-304.