Does systemic administration of casein phosphopeptides affect orthodontic movement and root resorption in rats?

Lachlan Crowther, Gang Shen, Mohammed Almuzian*, Allan Jones, William Walsh, Rema Oliver, Peter Petocz, Nour E. Tarraf, M. Ali Darendeliler

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    Objectives: To assess the potential effects of casein phosphopeptides (CPPs) on orthodontically induced iatrogenic root resorption (OIIRR) and orthodontic teeth movement.

    Materials and methods:Forty Wistar rats (aged 11 weeks) were randomly divided into experimental group (EG; n = 20) that received a diet supplemented with CPP and control group (CG; n = 20) devoid of diet supplement. A 150 g force was applied using nickel titanium (NiTi) coil that was bonded on maxillary incisors and extended unilaterally to a maxillary first molar. At Day 28, animals in both groups were euthanized. Volumetric assessment of root resorption craters and linear measurement of maxillary first molars movement were blindly examined using a micro-computed tomography scan.

    Results:Nine rats were excluded from the experiment due to loss during general anesthesia or appliances' failure. Intra-operator reproducibility was high in both volumetric and linear measurements, 92.8 per cent and 98.5-97.6 per cent, respectively. The results reveal that dietary CPP has statistically insignificant effect on the overall OIIRR and orthodontic movement.

    Conclusions:CPP seems to have statistically insignificant effect on the volume of OIIRR and orthodontic movement in rats. A long-term study with larger sample size using a different concentration of CPP is required to clarify the dentoalveolar effect of CPP.

    Original languageEnglish
    Pages (from-to)541-546
    Number of pages6
    JournalEuropean Journal of Orthodontics
    Volume39
    Issue number5
    DOIs
    Publication statusPublished - 1 Oct 2017

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