Does upper airway deformation affect drug deposition?

Shaokoon Cheng, Agisilaos Kourmatzis, Taye Mekonnen, Hanieh Gholizadeh, Joel Raco, Lan Chen, Patricia Tang, Hak-Kim Chan

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Knowledge that enables the accurate simulation of drug deposition in the human upper airway is necessary to develop robust platforms for efficient drug delivery by inhalation devices. The human upper airway is deformable during inhalation but how it could affect the deposition of inhaled drugs is unknown. We aimed to determine whether pharyngeal deformation at the soft palate level would have any significant effects on throat deposition, in vitro lung dose and fine particle fraction. In this study, dry mannitol powders were delivered to the next-generation cascade impactor (NGI) through the United States Pharmacopeia (USP) throat, and a realistic upper airway cast (RUPAC) at flow rates of 40, 60 and 80 L min−1. Deformation of the upper airway at 25%, 50%, and 75% in the lateral and antero-posterior directions were experimentally simulated in the RUPAC. Throat deposition (p = 0.04) is significantly affected when the upper airway deforms laterally but not antero-posteriorly.

LanguageEnglish
Article number118773
Pages1-8
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume572
Early online date31 Oct 2019
DOIs
Publication statusPublished - 15 Dec 2019

Fingerprint

Pharynx
Pharmaceutical Preparations
Soft Palate
Pharmacopoeias
Nebulizers and Vaporizers
Mannitol
Powders
Inhalation
Lung

Keywords

  • Pharynx collapse
  • Upper airway deformation
  • Throat deposition
  • In vitro lung dose
  • Fine particle fraction

Cite this

Cheng, Shaokoon ; Kourmatzis, Agisilaos ; Mekonnen, Taye ; Gholizadeh, Hanieh ; Raco, Joel ; Chen, Lan ; Tang, Patricia ; Chan, Hak-Kim. / Does upper airway deformation affect drug deposition?. In: International Journal of Pharmaceutics. 2019 ; Vol. 572. pp. 1-8.
@article{eadec3d9fdec4de38eacf4568a7ba8b7,
title = "Does upper airway deformation affect drug deposition?",
abstract = "Knowledge that enables the accurate simulation of drug deposition in the human upper airway is necessary to develop robust platforms for efficient drug delivery by inhalation devices. The human upper airway is deformable during inhalation but how it could affect the deposition of inhaled drugs is unknown. We aimed to determine whether pharyngeal deformation at the soft palate level would have any significant effects on throat deposition, in vitro lung dose and fine particle fraction. In this study, dry mannitol powders were delivered to the next-generation cascade impactor (NGI) through the United States Pharmacopeia (USP) throat, and a realistic upper airway cast (RUPAC) at flow rates of 40, 60 and 80 L min−1. Deformation of the upper airway at 25{\%}, 50{\%}, and 75{\%} in the lateral and antero-posterior directions were experimentally simulated in the RUPAC. Throat deposition (p = 0.04) is significantly affected when the upper airway deforms laterally but not antero-posteriorly.",
keywords = "Pharynx collapse, Upper airway deformation, Throat deposition, In vitro lung dose, Fine particle fraction",
author = "Shaokoon Cheng and Agisilaos Kourmatzis and Taye Mekonnen and Hanieh Gholizadeh and Joel Raco and Lan Chen and Patricia Tang and Hak-Kim Chan",
year = "2019",
month = "12",
day = "15",
doi = "10.1016/j.ijpharm.2019.118773",
language = "English",
volume = "572",
pages = "1--8",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",

}

Does upper airway deformation affect drug deposition? / Cheng, Shaokoon; Kourmatzis, Agisilaos; Mekonnen, Taye; Gholizadeh, Hanieh; Raco, Joel; Chen, Lan; Tang, Patricia; Chan, Hak-Kim.

In: International Journal of Pharmaceutics, Vol. 572, 118773, 15.12.2019, p. 1-8.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Does upper airway deformation affect drug deposition?

AU - Cheng, Shaokoon

AU - Kourmatzis, Agisilaos

AU - Mekonnen, Taye

AU - Gholizadeh, Hanieh

AU - Raco, Joel

AU - Chen, Lan

AU - Tang, Patricia

AU - Chan, Hak-Kim

PY - 2019/12/15

Y1 - 2019/12/15

N2 - Knowledge that enables the accurate simulation of drug deposition in the human upper airway is necessary to develop robust platforms for efficient drug delivery by inhalation devices. The human upper airway is deformable during inhalation but how it could affect the deposition of inhaled drugs is unknown. We aimed to determine whether pharyngeal deformation at the soft palate level would have any significant effects on throat deposition, in vitro lung dose and fine particle fraction. In this study, dry mannitol powders were delivered to the next-generation cascade impactor (NGI) through the United States Pharmacopeia (USP) throat, and a realistic upper airway cast (RUPAC) at flow rates of 40, 60 and 80 L min−1. Deformation of the upper airway at 25%, 50%, and 75% in the lateral and antero-posterior directions were experimentally simulated in the RUPAC. Throat deposition (p = 0.04) is significantly affected when the upper airway deforms laterally but not antero-posteriorly.

AB - Knowledge that enables the accurate simulation of drug deposition in the human upper airway is necessary to develop robust platforms for efficient drug delivery by inhalation devices. The human upper airway is deformable during inhalation but how it could affect the deposition of inhaled drugs is unknown. We aimed to determine whether pharyngeal deformation at the soft palate level would have any significant effects on throat deposition, in vitro lung dose and fine particle fraction. In this study, dry mannitol powders were delivered to the next-generation cascade impactor (NGI) through the United States Pharmacopeia (USP) throat, and a realistic upper airway cast (RUPAC) at flow rates of 40, 60 and 80 L min−1. Deformation of the upper airway at 25%, 50%, and 75% in the lateral and antero-posterior directions were experimentally simulated in the RUPAC. Throat deposition (p = 0.04) is significantly affected when the upper airway deforms laterally but not antero-posteriorly.

KW - Pharynx collapse

KW - Upper airway deformation

KW - Throat deposition

KW - In vitro lung dose

KW - Fine particle fraction

UR - http://www.scopus.com/inward/record.url?scp=85074967369&partnerID=8YFLogxK

UR - http://purl.org/au-research/grants/arc/DP190101237

UR - https://www.elsevier.com/about/policies/sharing

U2 - 10.1016/j.ijpharm.2019.118773

DO - 10.1016/j.ijpharm.2019.118773

M3 - Article

VL - 572

SP - 1

EP - 8

JO - International Journal of Pharmaceutics

T2 - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

M1 - 118773

ER -