Dopamine vs noradrenaline

Inverted-U effects and ADHD theories

Florence Levy*

*Corresponding author for this work

Research output: Contribution to journalReview article

48 Citations (Scopus)

Abstract

The aim of the present study was to review the dopamine theory of attention-deficit-hyperactivity disorder (ADHD), in light of recent use of noradrenergic therapies. A historical review of pharmacological theories of ADHD was conducted, including inverted-U, spatial working memory and neural circuit aspects. Pharmacological advances, including animal and human studies of dopaminergic and noradrenergic mechanisms at the prefrontal cortex (PFC), indicate that α-2A adrenoreceptor stimulation results in increased dendritic firing during delay periods for preferred directions, while moderate levels of D1 receptor stimulation result in reduction of delay-related firing to non-preferred directions, allowing representational control in the PFC. Recent studies of the COMT val/met gene and stimulant medication response may help explain variation in inverted-U responses in individuals. Further studies utilizing delay-related firing paradigms should be useful in the investigation of attentional syndromes, and responses to newer pharmacological treatments.

Original languageEnglish
Pages (from-to)101-108
Number of pages8
JournalAustralian and New Zealand Journal of Psychiatry
Volume43
Issue number2
DOIs
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • Attention-deficit-hyperactivity disorder
  • Dopamine
  • Inverted-U
  • Noradrenaline
  • Working memory

Fingerprint Dive into the research topics of 'Dopamine vs noradrenaline: Inverted-U effects and ADHD theories'. Together they form a unique fingerprint.

  • Cite this