Dosage of conventional neuroleptic medication and subjective cognitive functioning in schizophrenia

M. Krausz, S. Moritz*, M. Lambert, D. Naber

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Subjective cognitive and perceptual disturbances as assessed with the Frankfurt Complaint Questionnaire (FCQ) were correlated with chlorpromazine equivalents in 40 schizophrenic inpatients, who were treated with conventional neuroleptics. In line with previous research using 'objective' neuropsychological tests, both correlations and partial correlations (controlling for the effects of psychopathology, extrapyramidal symptoms and length of illness) confirmed that higher neuroleptic doses significantly worsen several cognitive and perceptual domains (r = 0.44-0.54; P ≤ 0.005-0.05) with the possible exception of mnestic functions (r = 0.21-0.24, n.s.) and language (r = 0.37-0.38, P ≤ 0.1). The clinical importance of self-report scales for evaluating both the risks and benefits of neuroleptic treatment is discussed. (C) 2000 Lippincott, Williams and Wilkins.

Original languageEnglish
Pages (from-to)77-81
Number of pages5
JournalInternational Clinical Psychopharmacology
Volume15
Issue number2
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • Cognition
  • Neuroleptics
  • Neuropsychology
  • Self-report
  • Side-effects

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