Dose response studies and longterm evaluation of auranofin in rheumatoid arthritis

G. D. Champion, D. R. Cairns, D. Bieri, M. A. Adena, C. D. Browne, M. L. Cohen, R. O. Day, J. P. Edmonds, G. G. Graham, J. De Jager, P. N. Sambrook

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)

    Abstract

    Fifty-eight patients with rheumatoid arthritis (RA) entered a double blind trial of auranofin (AF) designed to assess dose response relationships and longterm outcome. Multivariate analysis of repeated measures with trend analysis and discriminant function analysis of standard measures of RA activity were applied to a randomized double blind trial of AF at daily doses of 4, 6 and 8 mg over 6 months. Improvement occurred in each group. There was a highly significant (p < 0.001) linear trend in the 6 mg group, 73% of whom showed linear improvement. A significant correlation (p < 0.05) was found between response of individual patients and AF dose (mg/kg/day), but there was no significant correlation between dosage and mean steady state serum gold concentration. No significant correlation was seen between outcome and pretreatment demographic and disease variables. In a subsequent 6 month phase of dosage adjustment, aiming for optimal dosage, no advantage resulted from increasing the dose above 6 mg/day. Patients apparently benefiting from treatment continued an open longterm trial of AF. By 45 months, 33.5% had stopped treatment due to lack of efficacy and 14.5% due to toxicity, mainly rash and diarrhea.

    Original languageEnglish
    Pages (from-to)28-34
    Number of pages7
    JournalJournal of Rheumatology
    Volume15
    Issue number1
    Publication statusPublished - 1988

    Fingerprint

    Dive into the research topics of 'Dose response studies and longterm evaluation of auranofin in rheumatoid arthritis'. Together they form a unique fingerprint.

    Cite this